Amide Local Anesthetic Drug Class List

Drugs in Drug Class: Amide Local Anesthetic

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
B Braun Medical Inc	BUPIVACAINE HYDROCHLORIDE	bupivacaine hydrochloride	INJECTABLE;SPINAL	209087-001	Apr 2, 2019	AP	RX	No	No
Hospira	BUPIVACAINE HYDROCHLORIDE	bupivacaine hydrochloride	INJECTABLE;INJECTION	070583-001	Feb 17, 1987	AP	RX	No	No
Hospira	BUPIVACAINE HYDROCHLORIDE	bupivacaine hydrochloride	INJECTABLE;SPINAL	071810-001	Dec 11, 1987	AP	RX	No	No
Hospira	BUPIVACAINE HYDROCHLORIDE	bupivacaine hydrochloride	INJECTABLE;INJECTION	070584-001	Feb 17, 1986	AP	RX	No	No
Meitheal	BUPIVACAINE HYDROCHLORIDE	bupivacaine hydrochloride	INJECTABLE;INJECTION	216040-001	Dec 27, 2023	AP	RX	No	No
Thea Pharma	AKTEN	lidocaine hydrochloride	GEL;OPHTHALMIC	022221-001	Oct 7, 2008		RX	Yes	Yes			Y

Amide Local Anesthetic Market Analysis and Financial Projection

The amide local anesthetic market is experiencing robust growth driven by increasing surgical volumes and pharmaceutical innovations, while a competitive patent landscape underscores ongoing R&D efforts to enhance drug efficacy and delivery.

Market Dynamics

Growth Drivers

• Rising Surgical Demand: The global amide local anesthetic market, valued at $1.998 billion in 2024, is projected to reach $2.806 billion by 2031 (CAGR: 5.1%)[11][12]. This growth is fueled by increasing minimally invasive surgeries and outpatient procedures, particularly in dental, orthopedic, and obstetric applications[1][6][15].
• Aging Population: With 2 billion people aged 60+ by 2050, the need for surgical interventions and chronic pain management is accelerating demand[11][16].
• Drug Innovations: Long-acting formulations like liposomal bupivacaine (Exparel®) and new agents (e.g., articaine, ropivacaine) extend pain relief and reduce opioid dependency[1][6][11].

Market Segments

• Leading Drugs:
  • Lidocaine dominates with ~32% market share (2024) due to rapid onset and versatility in dental/surgical settings[7][15].
  • Bupivacaine grows at ~5% CAGR, favored for prolonged analgesic effects in post-operative care[7][11].
• Administration Routes: Injectable forms lead due to efficacy, but transdermal/topical options (e.g., lidocaine patches) are rising[1][14].
• Geographic Trends:
  • North America holds >40% market share, driven by high healthcare spending[11][15].
  • Asia-Pacific surges with expanding healthcare access and local manufacturing in India/China[11][12].

Patent Landscape

Key Innovations

Patent/Application	Focus Area	Impact
CN117069648A [3]	Prodrug-based oil injections	Prolongs anesthetic effect via slow drug release from lipid matrices
US5993836A [14]	Topical lidocaine/prilocaine blend	Enhances absorption and reduces systemic toxicity
USRE47826 [13]	Collagen matrix drug delivery	Enables sustained analgesia (≥1 day) post-administration
Pharmavax AS [18] (2024)	Amide + vasoconstrictor combinations	Improves localized efficacy and duration

Strategic Shifts

• Liposomal Formulations: Extend duration (e.g., Exparel® lasts 72+ hours)[7][11].
• Safety Enhancements: Addressing allergies (lidocaine linked to 11/16 allergic cases in French studies)[5], with skin testing recommended for cross-reactivity[5].
• Targeted Delivery: Patents focus on reducing injection frequency and improving site-specific effects[3][13].

Competitive Outlook

• Top Players: Pfizer, AstraZeneca, and Hikma Pharmaceuticals lead, investing in novel formulations[12].
• R&D Trends: Emphasis on adjuvants (e.g., dextrans) to prolong action and reduce toxicity[7][19].
• Challenges: Patent saturation necessitates differentiation through delivery systems and combination therapies[9][13].

The amide local anesthetic sector remains dynamic, balancing innovation with safety to meet escalating clinical demands.

References

1. https://www.researchandmarkets.com/reports/5302504/local-anesthesia-drugs-global-strategic
2. https://www.rxlist.com/how_do_amide_local_anesthetics_work/drug-class.htm
3. https://patents.google.com/patent/CN117069648A/en
4. https://www.thebusinessresearchcompany.com/report/anesthetics-global-market-report
5. https://onlinelibrary.wiley.com/doi/abs/10.1002/pds.1758
6. https://www.globenewswire.com/news-release/2023/07/12/2703842/0/en/Local-Anesthesia-Drugs-Global-Market-to-Proliferate-at-a-CAGR-of-4-by-2028-DelveInsight.html
7. https://www.mordorintelligence.com/industry-reports/local-anesthesia-drugs-market
8. https://matthew-ho-825h.squarespace.com/s/Local-Anaesthetics.pdf
9. https://www.drugpatentwatch.com/p/patent/5466700
10. https://journals.lww.com/md-journal/fulltext/2022/12020/the_potential_of_articaine_as_new_generation_of.18.aspx
11. https://pmarketresearch.com/product/worldwide-amide-local-anesthetics-market-research-2024-by-type-application-participants-and-countries-forecast-to-2030/
12. https://reports.valuates.com/market-reports/QYRE-Auto-38D18656/global-amides-anesthetic
13. https://www.drugpatentwatch.com/p/patent/RE47826
14. https://patents.google.com/patent/US5993836A/en
15. https://www.skyquestt.com/report/local-anesthesia-drugs-market
16. https://www.futuremarketinsights.com/reports/general-anesthesia-drugs-market
17. https://patents.justia.com/patents-by-us-classification/514/818
18. https://go.gale.com/ps/i.do?id=GALE%7CA809526312&sid=sitemap&v=2.1&it=r&p=HRCA&sw=w
19. https://patents.google.com/patent/US3160662A/en