Drug Price Trends for DARIFENACIN ER

Average Pharmacy Cost for DARIFENACIN ER

These are average pharmacy acquisition costs (net of discounts) from a US national survey

Drug Name	NDC	Price/Unit ($)	Unit	Date
DARIFENACIN ER 15 MG TABLET	13668-0203-90	0.31505	EACH	2025-03-19
DARIFENACIN ER 15 MG TABLET	16571-0768-09	0.31505	EACH	2025-03-19
DARIFENACIN ER 15 MG TABLET	33342-0277-07	0.31505	EACH	2025-03-19
DARIFENACIN ER 15 MG TABLET	16571-0768-03	0.31505	EACH	2025-03-19
DARIFENACIN ER 7.5 MG TABLET	70700-0182-90	0.60432	EACH	2025-03-19

Market Analysis and Price Projections for Darifenacin ER

Overview of Darifenacin ER

Darifenacin, marketed under the brand name Enablex, is a muscarinic M3 selective receptor antagonist used primarily to treat overactive bladder (OAB) symptoms, including urinary frequency, urgency, and incontinence. It is available in extended-release (ER) tablets in 7.5 mg and 15 mg doses.

Market Growth and Trends

The global darifenacin hydrobromide market is anticipated to experience significant growth. Here are some key trends and forecasts:

• Growth Rate: The global darifenacin hydrobromide market is expected to grow at a Compound Annual Growth Rate (CAGR) of 6.1% from 2024 to 2030[1].
• Market Size: The broader overactive bladder treatment market, which includes darifenacin, was valued at $3.5 billion in 2022 and is projected to reach $4.2 billion by 2027, growing at a CAGR of 3.6% from 2022 to 2027[3].

Drivers of Market Growth

Several factors are driving the growth of the darifenacin market:

• Increasing Prevalence of OAB: The rising number of patients with overactive bladder is a major driver. As the population ages, the incidence of OAB is expected to increase, thereby boosting demand for treatments like darifenacin[3].
• Adequate Reimbursement Policies: Favorable reimbursement policies for OAB treatments are also contributing to market growth[3].
• Investment in Novel Drugs and Devices: Increased investment in the development of new drugs and devices for OAB treatment is further expected to drive market expansion[3].

Market Segmentation

The darifenacin hydrobromide market can be segmented in several ways:

• By Type: The market is segmented into 7.5 mg and 15 mg doses of darifenacin ER tablets[1].
• By Application: The primary applications include hospitals, clinics, and other healthcare settings[1].
• By Region: The market is analyzed across North America, Europe, Asia Pacific, and the Rest of the World[1].

Pricing and Cost Analysis

The pricing of darifenacin ER tablets can vary based on several factors, including the pharmacy, location, and availability of generic versions.

• Brand Name (Enablex):
  • The cost for Enablex 7.5 mg oral tablet, extended release, is around $163 for a supply of 30 tablets[5].
  • For the 15 mg dose, the price is similarly around $162.71 for 30 tablets[5].
• Generic Version:
  • A generic version of darifenacin is available, with prices starting from $78.94 for 30 tablets of the 7.5 mg dose and $128.68 for 30 tablets of the 15 mg dose[2][5].

Patient Assistance and Discounts

To make darifenacin more affordable, several patient assistance programs and discount cards are available:

• Discount Cards: Programs like the Drugs.com Discount Card can save patients up to 80% or more off the cost of prescription medicines[5].
• Copay Cards and Patient Assistance: Various copay cards and patient assistance programs are offered to reduce the financial burden on patients[2][5].

Adverse Reactions and Safety Profile

While darifenacin is generally well-tolerated, it does come with some potential adverse reactions:

• Common Adverse Reactions: Dry mouth, constipation, nausea, pharyngitis, and diarrhea are among the most common adverse events reported[4].
• Serious Adverse Events: Rare but serious adverse events include generalized hypersensitivity reactions and acute urinary retention requiring treatment[4].

Pharmacokinetics and Pharmacodynamics

Darifenacin exhibits a high selectivity for the M3 muscarinic receptor, which is the major subtype modulating urinary bladder muscle contraction. Here are some key pharmacokinetic and pharmacodynamic points:

• Absorption and Bioavailability: Darifenacin is rapidly and completely absorbed after oral administration, with an estimated mean oral bioavailability of 15% and 19% for the 7.5 mg and 15 mg extended-release tablets, respectively[4].
• Half-Life: The estimated half-life for the extended-release tablet is between 12.8 to 18.7 hours[4].

Impact of COVID-19

The COVID-19 pandemic has had various impacts on pharmaceutical markets, including disruptions in supply chains and changes in patient behavior. However, the demand for OAB treatments like darifenacin has remained relatively stable due to the chronic nature of the condition.

Key Takeaways

• Market Growth: The darifenacin hydrobromide market is expected to grow at a CAGR of 6.1% from 2024 to 2030.
• Pricing: The cost of darifenacin ER tablets varies, with brand-name prices around $160 for a 30-tablet supply and generic versions significantly cheaper.
• Patient Assistance: Various discount cards and patient assistance programs are available to reduce costs.
• Safety Profile: Common adverse reactions include dry mouth and constipation, with rare but serious events such as acute urinary retention.
• Pharmacokinetics: Darifenacin has a high selectivity for the M3 muscarinic receptor and a half-life of 12.8 to 18.7 hours.

FAQs

Q: What is darifenacin used for? A: Darifenacin is used to treat overactive bladder symptoms, including urinary frequency, urgency, and incontinence.

Q: What are the common doses of darifenacin ER tablets? A: The common doses are 7.5 mg and 15 mg extended-release tablets.

Q: How much does darifenacin ER cost? A: The cost varies, but brand-name Enablex can cost around $160 for a 30-tablet supply, while generic versions start from around $79 for 30 tablets.

Q: What are the common adverse reactions to darifenacin? A: Common adverse reactions include dry mouth, constipation, nausea, pharyngitis, and diarrhea.

Q: Is darifenacin available in generic form? A: Yes, a generic version of darifenacin is available, which is significantly cheaper than the brand-name version.

Sources

1. Lucintel: Darifenacin Hydrobromide Market Report: Trends, Forecast and Competitive Analysis[1].
2. Drugs.com: Darifenacin Prices, Coupons, Copay Cards & Patient Assistance[2].
3. MarketsandMarkets: Overactive Bladder Treatment Market Size And Global Industry Analysis[3].
4. Health Canada: Darifenacin Extended Release Tablets[4].
5. Drugs.com: Enablex Prices, Coupons, Copay Cards & Patient Assistance[5].