Drug Price Trends for TIADYLT ER

Average Pharmacy Cost for TIADYLT ER

These are average pharmacy acquisition costs (net of discounts) from a US national survey

Drug Name	NDC	Price/Unit ($)	Unit	Date
TIADYLT ER 420 MG CAPSULE	68382-0750-16	0.96243	EACH	2025-03-19
TIADYLT ER 120 MG CAPSULE	68382-0745-16	0.23474	EACH	2025-03-19
TIADYLT ER 180 MG CAPSULE	68382-0746-16	0.33357	EACH	2025-03-19
TIADYLT ER 300 MG CAPSULE	68382-0748-16	0.56778	EACH	2025-03-19

Market Analysis and Price Projections for Tiadylt ER

Introduction to Tiadylt ER

Tiadylt ER, a formulation of diltiazem hydrochloride, is an extended-release capsule used primarily for the treatment of hypertension, angina pectoris, and certain heart rhythm disorders. It belongs to the class of calcium channel blockers, which work by inhibiting the influx of calcium ions into cardiac and vascular smooth muscle cells, thereby reducing blood pressure and improving heart function[4].

Market Approval and Manufacturing

Tiadylt ER received final approval from the US Food and Drug Administration (USFDA) in 2017, allowing Zydus Cadila to market the drug in multiple strengths: 120mg, 180mg, 240mg, 300mg, and 420mg. The drug is manufactured at Zydus Cadila's formulations manufacturing facility in Ahmedabad, India[1].

Clinical Indications and Usage

Tiadylt ER is indicated for the treatment of hypertension and can be used alone or in combination with other antihypertensive medications. It has also shown efficacy in managing chronic stable angina by increasing exercise tolerance and reducing the frequency of anginal attacks[4].

Pharmacodynamics and Pharmacokinetics

The drug demonstrates a dose-related antihypertensive response, with significant reductions in diastolic and systolic blood pressure observed in clinical trials. It also exhibits non-linear pharmacokinetics, with a more than proportional increase in diltiazem plasma concentrations as the dose is increased from 120 mg to 540 mg[3][4].

Market Demand and Competition

The market demand for antihypertensive medications is high due to the prevalence of hypertension worldwide. Tiadylt ER competes with other calcium channel blockers and extended-release formulations such as Dilt-XR. The competition in this market segment is intense, with multiple generic and branded options available.

Pricing and Cost Analysis

The pricing of Tiadylt ER varies based on the dosage and the pharmacy. Here is a breakdown of the prices for different strengths:

• 120 mg/24 hours: Around $37 for a supply of 90 capsules[2].
• 180 mg/24 hours: Around $45.54 for a supply of 90 capsules[2].
• 240 mg/24 hours: Around $57.44 for a supply of 90 capsules[2].
• 300 mg/24 hours: Around $129.28 for a supply of 90 capsules[2].
• 420 mg/24 hours: Around $128.51 for a supply of 90 capsules[2].

Price Projections

Given the competitive nature of the market and the availability of generic alternatives, price stability or slight decreases can be expected in the short term. Here are some key factors influencing price projections:

• Generic Competition: The presence of generic alternatives like Dilt-XR, which offer similar efficacy at competitive prices, can drive down the prices of Tiadylt ER[5].
• Market Dynamics: The overall demand for antihypertensive medications is likely to remain high, but pricing will be influenced by the availability of other treatment options and the negotiating power of healthcare providers and insurance companies.
• Regulatory Environment: Any changes in regulatory policies or approvals for new drugs could impact the pricing strategy of Tiadylt ER.

Patient Assistance and Discounts

To make the drug more accessible, various patient assistance programs, coupons, and copay cards are available. For example, the Drugs.com discount card can save patients up to 80% on the cost of Tiadylt ER and other prescription medications[2][5].

Future Outlook

The future outlook for Tiadylt ER is influenced by several factors:

• Innovation: Continuous innovation in drug delivery systems and the development of new antihypertensive agents could impact market share.
• Market Expansion: Zydus Cadila's ability to expand its market reach, both geographically and through strategic partnerships, will be crucial.
• Regulatory Compliance: Maintaining compliance with regulatory standards and obtaining approvals for new indications or formulations will be essential for long-term success.

Key Takeaways

• Market Approval: Tiadylt ER has received USFDA approval for multiple strengths.
• Clinical Efficacy: Demonstrates dose-related antihypertensive and anti-anginal effects.
• Pricing: Competitive pricing with generic alternatives available.
• Patient Assistance: Various discount programs and patient assistance options available.
• Future Outlook: Dependent on innovation, market expansion, and regulatory compliance.

Frequently Asked Questions (FAQs)

Q1: What is Tiadylt ER used for? Tiadylt ER is used for the treatment of hypertension, angina pectoris, and certain heart rhythm disorders.

Q2: How does Tiadylt ER work? Tiadylt ER works by inhibiting the influx of calcium ions into cardiac and vascular smooth muscle cells, thereby reducing blood pressure and improving heart function.

Q3: What are the available strengths of Tiadylt ER? Tiadylt ER is available in strengths of 120mg, 180mg, 240mg, 300mg, and 420mg.

Q4: How much does Tiadylt ER cost? The cost varies by strength and pharmacy, but for example, a 90-capsule supply of 120mg Tiadylt ER costs around $37.

Q5: Are there any patient assistance programs for Tiadylt ER? Yes, various patient assistance programs, coupons, and copay cards are available to make Tiadylt ER more affordable.

Sources:

1. Business Standard - Zydus Cadila receives USFDA approval to market blood pressure drug[1].
2. Drugs.com - Tiadylt ER Prices, Coupons, Copay Cards & Patient Assistance[2].
3. DailyMed - TIADYLT ER- diltiazem hydrochloride capsule, extended release[3].
4. Drugs.com - Tiadylt ER: Package Insert / Prescribing Information[4].
5. Drugs.com - Dilt-XR Prices, Coupons, Copay Cards & Patient Assistance[5].