Drug Price Trends for phenelzine sulfate

Average Pharmacy Cost for phenelzine sulfate

These are average pharmacy acquisition costs (net of discounts) from a US national survey

Drug Name	NDC	Price/Unit ($)	Unit	Date
PHENELZINE SULFATE 15 MG TAB	59762-0119-01	0.57936	EACH	2025-04-23
PHENELZINE SULFATE 15 MG TAB	59762-0119-01	0.57320	EACH	2025-03-19
PHENELZINE SULFATE 15 MG TAB	59762-0119-01	0.55779	EACH	2025-02-19
PHENELZINE SULFATE 15 MG TAB	43386-0360-21	0.53842	EACH	2025-01-22
PHENELZINE SULFATE 15 MG TAB	59762-0119-01	0.53842	EACH	2025-01-22

Market Analysis and Price Projections for Phenelzine Sulfate

Introduction

Phenelzine sulfate, commonly known by the brand name Nardil, is a monoamine oxidase inhibitor (MAOI) used primarily for the treatment of depression, particularly in patients who have not responded to other antidepressants. Here, we will delve into the market analysis and price projections for this medication.

Market Demand and Usage

Phenelzine sulfate is indicated for patients with atypical, nonendogenous, or neurotic depression, often characterized by mixed anxiety and depression, and phobic or hypochondriacal features. Despite its efficacy, it is rarely used as a first-line treatment due to its potential for serious adverse effects and drug interactions[4].

The demand for phenelzine sulfate is relatively niche compared to other antidepressants. It is more commonly prescribed for patients who have failed to respond to other treatments, which limits its broader market appeal. However, its unique efficacy profile, particularly in treatment-resistant depression, maintains a steady demand in specific clinical settings[3].

Supply Chain and Availability

The supply of phenelzine sulfate has faced significant challenges. There have been reported shortages in several jurisdictions, including the United States, the United Kingdom, Canada, and Australia. These shortages are partly due to manufacturing issues and the discontinuation of certain branded products[1][3].

For instance, in 2020, there was a notable supply issue with Nardil, leading to the use of alternative products under Section 29 approvals. The stock levels were critically low, with only about one month's supply available at the time[1].

Pricing and Cost Analysis

The pricing of phenelzine sulfate varies significantly depending on the region and the specific product (brand or generic).

• Generic Version: The cost for a generic version of phenelzine sulfate (15 mg oral tablet) can range from approximately $44.57 to $60 for a supply of 60 tablets in the United States. This price is influenced by the use of discount cards and can vary between pharmacies[2][5].
• Brand Name (Nardil): The brand name version, Nardil, is more expensive, with a cost of around $171 for a supply of 60 tablets[5].

Global Pricing Variations

The cost of phenelzine sulfate also varies globally. For example:

• In the United Kingdom, the annual cost for 60 mg/day of phenelzine was reported to be £327.60 in 2018, significantly higher than other commonly used antidepressants[3].
• In Canada, the cost was reported as Can$ 144.95 for 180 tablets, and in the United States, it was US$ 108.88 for 60 tablets[3].

Price Projections

Given the ongoing supply issues and the specialized nature of phenelzine sulfate, price projections are challenging but can be inferred from several factors:

• Supply Shortages: Continued shortages are likely to drive prices up due to demand outpacing supply. This has been observed in the past, where increased demand due to stockpiling by wholesalers and pharmacists has depleted stock levels quickly[1].
• Regulatory and Manufacturing Factors: Any changes in regulatory requirements or manufacturing processes could impact the availability and cost of the drug.
• Market Competition: The availability of generic versions may help stabilize prices, but the niche market for phenelzine sulfate means that competition is limited, which could keep prices relatively high.

Economic and Clinical Considerations

Phenelzine sulfate, despite its high cost, is considered the third most cost-effective intervention for certain types of depression after cognitive behavioral therapy. However, its use is limited by the need for careful monitoring and the potential for serious adverse effects, which adds to the overall cost of treatment[3].

Conclusion

Phenelzine sulfate remains a critical medication for a specific subset of patients with depression, particularly those who have not responded to other treatments. However, its market is characterized by supply shortages, high costs, and a need for specialized monitoring.

Key Takeaways

• Niche Market: Phenelzine sulfate is used for treatment-resistant depression and has a niche market.
• Supply Issues: Ongoing supply shortages affect the availability and pricing of the drug.
• Pricing Variability: Prices vary significantly between generic and brand versions and across different regions.
• Economic Considerations: Despite high costs, phenelzine sulfate is considered cost-effective in certain clinical contexts.
• Clinical Monitoring: The need for careful monitoring due to potential adverse effects adds to the overall cost of treatment.

FAQs

1. What is phenelzine sulfate used for? Phenelzine sulfate is primarily used for the treatment of depression, especially in patients who have not responded to other antidepressants.

2. Why are there supply shortages of phenelzine sulfate? Supply shortages are due to manufacturing issues, discontinuation of certain products, and increased demand leading to stockpiling.

3. How much does phenelzine sulfate cost? The cost varies; the generic version can range from $44.57 to $60 for 60 tablets, while the brand name Nardil can cost around $171 for 60 tablets.

4. Is phenelzine sulfate cost-effective? Despite its high cost, phenelzine sulfate is considered the third most cost-effective intervention for certain types of depression after cognitive behavioral therapy.

5. What are the potential risks associated with phenelzine sulfate? Phenelzine sulfate is associated with potentially serious adverse effects, including drug-drug and drug-food interactions, and requires careful monitoring.

Sources

1. Pharmac.govt.nz - Communications regarding phenelzine discontinuation
2. Drugs.com - Phenelzine Prices, Coupons, Copay Cards & Patient Assistance
3. Essentialmeds.org - Phenelzine - eEML - Electronic Essential Medicines List
4. Dailymed.nlm.nih.gov - Label: PHENELZINE SULFATE tablet
5. Drugs.com - Nardil Prices, Coupons, Copay Cards & Patient Assistance