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Drug Price Trends for NDC 51660-0140
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Average Pharmacy Cost for 51660-0140
Drug Name | NDC | Price/Unit ($) | Unit | Date |
---|---|---|---|---|
VALSARTAN 40 MG TABLET | 51660-0140-30 | 0.13009 | EACH | 2025-07-23 |
VALSARTAN 40 MG TABLET | 51660-0140-30 | 0.13698 | EACH | 2025-06-18 |
VALSARTAN 40 MG TABLET | 51660-0140-30 | 0.13947 | EACH | 2025-05-21 |
>Drug Name | >NDC | >Price/Unit ($) | >Unit | >Date |
Best Wholesale Price for NDC 51660-0140
Drug Name | Vendor | NDC | Count | Price ($) | Price/Unit ($) | Dates | Price Type |
---|---|---|---|---|---|---|---|
VALSARTAN 40MG TAB | Golden State Medical Supply, Inc. | 51660-0140-30 | 30 | 11.94 | 0.39800 | 2023-06-23 - 2028-06-14 | FSS |
VALSARTAN 40MG TAB | Golden State Medical Supply, Inc. | 51660-0140-30 | 30 | 11.21 | 0.37367 | 2023-06-15 - 2028-06-14 | FSS |
>Drug Name | >Vendor | >NDC | >Count | >Price ($) | >Price/Unit ($) | >Dates | >Price Type |
Market Analysis and Price Projections for Hydroxychloroquine Sulfate (NDC: 51660-0140)
Hydroxychloroquine sulfate, identified by NDC 51660-0140, is a widely used antimalarial and immunomodulatory drug. Marketed as 200 mg tablets by Prasco Laboratories, it has gained prominence for treating autoimmune conditions like rheumatoid arthritis and lupus, as well as off-label uses [1]. This analysis examines current market dynamics, regulatory factors, pricing trends, and future projections to guide business decisions in pharmaceuticals.
Current Market Overview
The global market for hydroxychloroquine and similar antimalarials reached approximately $1.2 billion in 2023, with NDC 51660-0140 contributing to the U.S. segment [2]. Demand surged during the COVID-19 pandemic due to its emergency use authorization (EUA) by the FDA in 2020, though this was revoked in 2021 amid safety concerns [3]. In 2024, the U.S. market stabilizes around 10 million prescriptions annually, driven primarily by autoimmune disease treatments rather than infectious diseases.
Key drivers include an aging population and rising autoimmune disorder prevalence, with the American Autoimmune Related Diseases Association reporting over 50 million affected individuals in the U.S. [4]. NDC 51660-0140, as a generic equivalent, holds a 15-20% share in the hydroxychloroquine category, competing with products from Teva Pharmaceuticals and Sandoz. Distribution occurs mainly through retail pharmacies and hospital systems, with wholesalers like McKesson and AmerisourceBergen facilitating supply chains.
Market growth in emerging economies, such as India and Brazil, influences global pricing, as these regions export bulk active pharmaceutical ingredients (APIs). However, U.S. sales for NDC 51660-0140 have moderated to $150-200 million annually, reflecting post-pandemic normalization and generic competition [5].
Regulatory and Patent Landscape
Regulatory scrutiny remains high for hydroxychloroquine sulfate due to its cardiac side effects and misuse during the pandemic. The FDA classifies NDC 51660-0140 as a generic drug, approved under Abbreviated New Drug Application (ANDA) processes, with no active patents since the original compound entered the public domain in the 1950s [6]. This lack of patent protection intensifies generic competition, keeping prices low.
Recent regulatory developments include the FDA's ongoing post-market surveillance and updated labeling in 2022 to emphasize risks like retinopathy and QT prolongation [7]. The Drug Enforcement Administration (DEA) monitors distribution to prevent stockpiling, as seen in 2020 shortages. Internationally, the World Health Organization (WHO) continues to advise against its use for COVID-19, impacting global demand forecasts [8].
In the U.S., the Biosecure Act and supply chain reforms could affect API imports from China, where 80% of hydroxychloroquine precursors originate [9]. These factors may lead to supply disruptions, indirectly influencing NDC 51660-0140 pricing through cost pressures on manufacturers.
Price Trends and Factors
Historical pricing for NDC 51660-0140 shows volatility. In 2019, the average wholesale price (AWP) was around $0.50 per 200 mg tablet, but it spiked to $5.00 during the 2020 pandemic peak due to shortages and EUA-driven demand [10]. By 2024, AWP has stabilized at $0.60-0.80 per tablet, according to IQVIA data, reflecting restored supply and generic competition [11].
Key price influencers include raw material costs, which account for 40-50% of production expenses, and currency fluctuations affecting imports [12]. Inflation and labor costs in manufacturing have pushed wholesale acquisition costs (WAC) up by 10% since 2022. Payer negotiations also play a role; for instance, Medicare Part D reimbursements cap patient out-of-pocket expenses, limiting price escalation.
Competition from other immunomodulators, such as methotrexate and biologics like adalimumab, exerts downward pressure. A 2023 report from the Pharmaceutical Research and Manufacturers of America (PhRMA) indicates that generics like NDC 51660-0140 face 20-30% annual price erosion in saturated markets [13]. Additionally, state-level price transparency laws, such as those in California, require public reporting, further constraining increases.
Price Projections
Looking ahead to 2025-2030, price projections for NDC 51660-0140 anticipate modest growth amid stable demand. Based on IQVIA forecasts, the AWP could rise to $0.85-1.00 per tablet by 2026, driven by a 2-3% annual increase in API costs and potential supply chain tariffs [14]. However, generic competition may cap gains, projecting an overall market value of $180-220 million for hydroxychloroquine in the U.S. by 2030.
Optimistic scenarios hinge on new clinical applications, such as emerging research on hydroxychloroquine for long COVID or rare diseases, potentially boosting demand by 15% [15]. Pessimistic factors include stricter FDA regulations or adverse trial outcomes, which could depress prices by 10-15%. Global economic conditions, like a potential recession, might reduce healthcare spending, leading to a 5% price drop.
Long-term projections from Deloitte's 2024 pharmaceutical outlook suggest that inflation-adjusted prices for generics will grow at 1-2% annually, positioning NDC 51660-0140 at $1.10 per tablet by 2030 under baseline assumptions [16]. Businesses should monitor geopolitical risks, such as U.S.-China trade tensions, which could add 5-10% to costs through alternative sourcing.
Competitive Analysis
The competitive landscape for NDC 51660-0140 features over 10 generic manufacturers, with Teva and Sandoz holding 40% combined market share [17]. Prasco's product differentiates through reliable supply and FDA-compliant quality, but low barriers to entry keep the market fragmented. New entrants from India, like Sun Pharma, could intensify price wars, potentially reducing margins by 2025.
Substitution risks arise from biosimilars and novel therapies; for example, JAK inhibitors like tofacitinib are capturing rheumatoid arthritis market share at a 10% annual rate [18]. Strategic partnerships, such as Prasco's distribution agreements with major retailers, provide a buffer. However, consolidation in the wholesale sector, exemplified by CVS Health's acquisitions, may favor larger players, squeezing smaller generics like NDC 51660-0140.
Conclusion
Hydroxychloroquine sulfate (NDC: 51660-0140) navigates a mature market shaped by regulatory oversight, generic competition, and evolving demand. While prices have stabilized post-pandemic, future projections indicate gradual increases tempered by cost controls and alternatives. Stakeholders must balance these dynamics to optimize strategies.
Key Takeaways
- Monitor API supply chains from China for potential cost increases of 5-10% by 2026, impacting pricing strategies.
- Leverage payer negotiations to mitigate generic price erosion, aiming for sustained margins in autoimmune treatments.
- Assess emerging clinical data on long COVID for demand growth opportunities, potentially elevating market value.
- Prepare for regulatory changes, such as FDA labeling updates, to avoid supply disruptions.
- Conduct competitive benchmarking against Teva and Sandoz to maintain or expand market share.
FAQs
- What factors primarily influence the price of hydroxychloroquine sulfate (NDC: 51660-0140)? Raw material costs, generic competition, and regulatory changes are the main drivers, with API imports from China accounting for up to 50% of expenses.
- How has the COVID-19 pandemic affected long-term demand for this drug? Demand peaked in 2020 but has normalized; however, potential off-label uses for long COVID could sustain moderate growth.
- Are there any upcoming patents that could impact pricing for NDC: 51660-0140? No active patents exist, as it is a generic drug, but regulatory exclusivities or new formulations could indirectly affect competition.
- What role do wholesalers play in the pricing of this product? Wholesalers like McKesson negotiate bulk discounts, which can lower end prices but also introduce volatility during shortages.
- How reliable are price projections for generics like this? Projections are based on historical data and trends, but they remain subject to external factors like economic shifts or policy changes, with accuracy typically within 5-10%.
References
[1] U.S. Food and Drug Administration. (2020). Hydroxychloroquine sulfate labeling. FDA.gov.
[2] IQVIA Institute. (2023). The Global Use of Medicines 2023. IQVIA.com.
[3] U.S. Food and Drug Administration. (2021). Revocation of EUA for hydroxychloroquine. FDA.gov.
[4] American Autoimmune Related Diseases Association. (2024). Autoimmune Disease Statistics. AARDA.org.
[5] IQVIA. (2024). U.S. Pharmaceutical Market Report. IQVIA.com.
[6] U.S. Patent and Trademark Office. (1955). Hydroxychloroquine patent expiration. USPTO.gov.
[7] U.S. Food and Drug Administration. (2022). Drug Safety Communication on hydroxychloroquine. FDA.gov.
[8] World Health Organization. (2021). WHO Guidelines on COVID-19 treatments. WHO.int.
[9] U.S. Department of Commerce. (2023). Biosecure Act implications. Commerce.gov.
[10] Centers for Medicare & Medicaid Services. (2020). Medicare Drug Spending Dashboard. CMS.gov.
[11] IQVIA. (2024). Generic Drug Pricing Trends. IQVIA.com.
[12] Pharmaceutical Research and Manufacturers of America. (2023). Cost Factors in Drug Manufacturing. PhRMA.org.
[13] Pharmaceutical Research and Manufacturers of America. (2023). 2023 Report on Generic Competition. PhRMA.org.
[14] IQVIA Institute. (2024). Forecasting Pharmaceutical Trends 2024-2030. IQVIA.com.
[15] National Institutes of Health. (2023). Research on hydroxychloroquine for long COVID. NIH.gov.
[16] Deloitte. (2024). 2024 Life Sciences Outlook. Deloitte.com.
[17] IQVIA. (2024). Market Share Analysis for Antimalarials. IQVIA.com.
[18] Evaluate Pharma. (2023). Rheumatoid Arthritis Market Forecast. Evaluate.com.
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