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Last Updated: December 13, 2024

CLINICAL TRIALS PROFILE FOR AG-881


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Clinical Trials for AG-881

Trial ID Title Status Sponsor Phase Summary
NCT02481154 ↗ Study of Orally Administered AG-881 in Patients With Advanced Solid Tumors, Including Gliomas, With an IDH1 and/or IDH2 Mutation Active, not recruiting Agios Pharmaceuticals, Inc. Phase 1 This study evaluates the safety, pharmacokinetics, pharmacodynamics and clinical activity of AG-881 in Gliomas, that harbor an IDH1 and/or IDH2 mutation.
NCT02481154 ↗ Study of Orally Administered AG-881 in Patients With Advanced Solid Tumors, Including Gliomas, With an IDH1 and/or IDH2 Mutation Active, not recruiting Institut de Recherches Internationales Servier Phase 1 This study evaluates the safety, pharmacokinetics, pharmacodynamics and clinical activity of AG-881 in Gliomas, that harbor an IDH1 and/or IDH2 mutation.
NCT02492737 ↗ Study of Orally Administered AG-881 in Patients With Advanced Hematologic Malignancies With an IDH1 and/or IDH2 Mutation Completed Agios Pharmaceuticals, Inc. Phase 1 The purpose of this Phase I, multicenter study is to evaluate the safety, pharmacokinetics, pharmacodynamics and clinical activity of AG-881 in advanced hematologic malignancies that harbor an IDH1 and/or IDH2 mutation
NCT03343197 ↗ Study of AG-120 and AG-881 in Subjects With Low Grade Glioma Active, not recruiting Agios Pharmaceuticals, Inc. Phase 1 Study to evaluate the suppression of 2-HG (2-hydroxyglutarate) in IDH-1 mutant gliomas in resected tumor tissue following pre-surgical treatment with AG-120 or AG-881.
NCT03343197 ↗ Study of AG-120 and AG-881 in Subjects With Low Grade Glioma Active, not recruiting Institut de Recherches Internationales Servier Phase 1 Study to evaluate the suppression of 2-HG (2-hydroxyglutarate) in IDH-1 mutant gliomas in resected tumor tissue following pre-surgical treatment with AG-120 or AG-881.
>Trial ID >Title >Status >Phase >Summary

Clinical Trial Conditions for AG-881

Condition Name

Condition Name
Intervention Trials
Glioma 2
Healthy Volunteers 2
Grade 2 Glioma 1
Healthy Male Participants 1
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Condition MeSH

Condition MeSH
Intervention Trials
Glioma 3
Leukemia, Myeloid 1
Liver Diseases 1
Hematologic Neoplasms 1
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Clinical Trial Locations for AG-881

Trials by Country

Trials by Country
Location Trials
United States 48
Canada 3
Netherlands 2
United Kingdom 2
France 2
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Trials by US State

Trials by US State
Location Trials
Texas 4
New York 4
Massachusetts 4
California 4
Arizona 3
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Clinical Trial Progress for AG-881

Clinical Trial Phase

Clinical Trial Phase
Clinical Trial Phase Trials
Phase 3 1
Phase 1 9
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Clinical Trial Status

Clinical Trial Status
Clinical Trial Phase Trials
Completed 5
Active, not recruiting 2
Not yet recruiting 2
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Clinical Trial Sponsors for AG-881

Sponsor Name

Sponsor Name
Sponsor Trials
Agios Pharmaceuticals, Inc. 8
Institut de Recherches Internationales Servier 5
Merck Sharp & Dohme LLC 1
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Sponsor Type

Sponsor Type
Sponsor Trials
Industry 9
Other 5
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