Chidamide in Combination With Carboplatin and Paclitaxel in Advanced Non-small Cell Lung Cancer
Completed
Chipscreen Biosciences, Ltd.
Phase 2
The purpose of this study is to evaluate the efficacy and safety of Chidamide combined with
paclitaxel and carboplatin in patients with advanced non-small-cell lung cancer.
Trial of Chidamide in Combination With Exemestane in Patients With Advanced Breast Cancer
Active, not recruiting
Chipscreen Biosciences, Ltd.
Phase 3
This study was to evaluate the efficacy and safety of Chidamide in combination with
exemestane in postmenopausal patients with hormone-receptor positive advanced breast cancer.
Chidamide in Combination With Antiretroviral Therapy for Eradication of the Latent HIV-1 Reservoir
Completed
Chipscreen Biosciences, Ltd.
Phase 1/Phase 2
HIV replication can be effectively suppressed and acquired immunodeficiency syndrome(AIDS)
can be prevented with highly active antiretroviral therapy (HAART). However, HIV-infected
people must remain on treatment continuously to avoid viral rebound and progression to AIDS.
HIV persistence is thought to stem primarily from the presence of integrated copies of the
proviral genome within long-lived cells. Because active viral gene expression causes cell
death due to viral cytopathic effects and the immune response, long-lived cells likely harbor
transcriptionally silent, latent provirus. HIV-1 persistence in long-lived cellular
reservoirs remains a major barrier to a cure. HDACi have the potential to activate ("Kick")
these latently infected cells. This will make the HIV infected cells visible to the immune
system; the immune response and antiretrovirals(ARVs) will be able to attack and eliminate
("Kill") the infected cells. The purpose of this study is to evaluate the safety and efficacy
of multi-dose Chidamide in combination with antiretroviral therapy in HIV-infected adults
with suppressed viral load.
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