ADX48621 for the Treatment of Levodopa Induced Dyskinesia in Patients With Parkinson's Disease
Completed
Addex Pharma S.A.
Phase 2
The primary objective of the study is to evaluate the safety and tolerability of ADX48621 in
Parkinson's disease patients following four weeks of dosing.
The secondary objectives of the study include the evaluation of the efficacy of ADX48621
compared with placebo in reducing levodopa induced dyskinesia in patients with Parkinson's;
the evaluation of the effect of ADX48621 on symptoms of Parkinson's disease and patient
ability to function, and the evaluation of the effect of coadministration of ADX48621 on
L-dopa efficacy.
PET Imaging Study to Evaluate the mGlu5r Occupancy Following ADX48621 (Dipraglurant) Administration
Completed
Addex Pharma S.A.
Phase 1
This is an open label study, non-randomized, positron emission tomography (PET)study
investigating mGlu5 receptor occupancy after single or two oral dosing of ADX48621 in healthy
subjects using [18F]-FPEB as the radiotracer.
PET Imaging Study to Evaluate the mGlu5r Occupancy Following ADX48621 (Dipraglurant) Administration
Completed
Johns Hopkins University
Phase 1
This is an open label study, non-randomized, positron emission tomography (PET)study
investigating mGlu5 receptor occupancy after single or two oral dosing of ADX48621 in healthy
subjects using [18F]-FPEB as the radiotracer.
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