CLINICAL TRIALS PROFILE FOR EPETRABOROLE

Clinical Trials for Epetraborole

Trial ID	Title	Status	Sponsor	Phase	Summary
NCT04892641 ↗	Phase 1 Study of Epetraborole Tablets	Recruiting	AN2 Therapeutics, Inc	Phase 1	This is a Phase 1b double-blind, placebo-controlled, dose-ranging study to evaluate the safety, tolerability, PK, and food effect of epetraborole tablets administered to healthy adult subjects for up to 28 days.
NCT05283746 ↗	A Phase 1 of Epetraborole Tablets	Recruiting	AN2 Therapeutics, Inc	Phase 1	This is a Phase 1 study to evaluate the pharmacokinetics (PK), safety and tolerability of epetraborole tablets in adult subjects with normal renal function, subjects with various degrees of renal impairment, and subjects with end-stage renal disease (ESRD) receiving intermittent hemodialysis (IHD) therapy.
NCT05327803 ↗	Study of Epetraborole in Patients With Treatment-refractory MAC Lung Disease	Not yet recruiting	AN2 Therapeutics, Inc	Phase 2/Phase 3	This pivotal Phase 2/3, double-blind, placebo-controlled study of epetraborole + OBR (Optimized Background Regimen) versus placebo + OBR in patients with treatment-refractory MAC lung disease. This study will enroll adult patients with treatment-refractory MAC lung disease who meet all eligibility criteria (including clinical, radiographic, and microbiological criteria).
NCT05995444 ↗	A Study to Assess the Effects of Epetraborole on the QT Interval in Healthy Adult Subjects	Completed	AN2 Therapeutics, Inc	Phase 1	A single-center, 4-way crossover study to evaluate the effect of single therapeutic and supratherapeutic oral doses of epetraborole on the heart rate (HR) corrected QT interval (QTc) by assessing concentration-QT (C-QT) relationship using exposure-response modeling.

Clinical Trial Conditions for Epetraborole

Condition Name

Condition Name
Intervention	Trials
Healthy Volunteers	2
Renal Insufficiency	1
MAC Lung Disease	1

Condition MeSH

Condition MeSH
Intervention	Trials
Renal Insufficiency	1
Lung Diseases	1

Clinical Trial Locations for Epetraborole

Trials by Country

Trials by Country
Location	Trials
United States	3
Australia	1

Trials by US State

Trials by US State
Location	Trials
Arizona	1
Minnesota	1
Florida	1

Clinical Trial Progress for Epetraborole

Clinical Trial Phase

Clinical Trial Phase
Clinical Trial Phase	Trials
Phase 2/Phase 3	1
Phase 1	3

Clinical Trial Status

Clinical Trial Status
Clinical Trial Phase	Trials
Recruiting	2
Not yet recruiting	1
Completed	1

Clinical Trial Sponsors for Epetraborole

Sponsor Name

Sponsor Name
Sponsor	Trials
AN2 Therapeutics, Inc	4

Sponsor Type

Sponsor Type
Sponsor	Trials
Industry	4