CLINICAL TRIALS PROFILE FOR ERITORAN
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Clinical Trials for Eritoran
Trial ID | Title | Status | Sponsor | Phase | Summary |
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NCT00334828 ↗ | ACCESS: A Controlled Comparison of Eritoran Tetrasodium and Placebo in Patients With Severe Sepsis | Completed | Eisai Inc. | Phase 3 | The purpose of this study is to compare eritoran tetrasodium and placebo in patients with severe sepsis and to demonstrate a reduction of mortality from all causes. |
NCT00756912 ↗ | A Study of Eritoran (E5564) Administered IV Over 14 Days Prior to and During Bone Marrow Engraftment in BMT Patients Who Have Received Myeloablative Conditioning Treatment and Are Receiving Bone Marrow or Stem Cells From Matched Related Donors | Terminated | Eisai Inc. | Phase 1 | This is a study designed to assess the safety of administration of up to 3 dose levels of eritoran in subjects undergoing or scheduled to undergo allogeneic bone marrow transplant (BMT). An allogeneic BMT is the transplantation of blood stem cells taken from the bone marrow or blood of another person. |
NCT02267317 ↗ | The Effect of TLR4 Inhibition in Obese and Type 2 Diabetic Subjects | Terminated | Nicolas Musi | Phase 2 | To determine whether pharmacologic inhibition of Toll-like receptor 4 (TLR4) with eritoran for injection (E5564) will reduce inflammation and improve glucose metabolism in insulin resistant (obese and T2DM) subjects. |
NCT02267317 ↗ | The Effect of TLR4 Inhibition in Obese and Type 2 Diabetic Subjects | Terminated | The University of Texas Health Science Center at San Antonio | Phase 2 | To determine whether pharmacologic inhibition of Toll-like receptor 4 (TLR4) with eritoran for injection (E5564) will reduce inflammation and improve glucose metabolism in insulin resistant (obese and T2DM) subjects. |
NCT02321111 ↗ | The Role of TLR4 on Lipid-induced Insulin Resistance | Completed | The University of Texas Health Science Center at San Antonio | Phase 2 | The purpose of this study is to determine whether pharmacologic inhibition of Toll-like receptor 4 (TLR4) with eritoran for injection (E5564) prevents lipid-induced insulin resistance in lean, normal glucose tolerant (NGT) subjects. |
NCT02735707 ↗ | Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia | Recruiting | Australian and New Zealand Intensive Care Research Centre | Phase 4 | REMAP-CAP is a randomised, embedded, multifactorial, adaptive platform trial for community-acquired pneumonia. The purpose of this study is to evaluate the effect of a range of interventions to improve outcome of patients admitted to intensive care with community-acquired pneumonia. In addition, REMAP-CAP provides and adaptive research platform for evaluation of multiple treatment modalities in the event of a respiratory pandemic resulting in critical illness. REMAP-COVID is a sub-platform of REMAP-CAP that evaluates treatments specific to COVID-19. |
>Trial ID | >Title | >Status | >Sponsor | >Phase | >Summary |
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