CLINICAL TRIALS PROFILE FOR FLUOROPYRIMIDINE

Clinical Trials for Fluoropyrimidine

Trial ID	Title	Status	Sponsor	Phase	Summary
NCT00002842 ↗	Liver Resection and Floxuridine Plus Fluorouracil and Leucovorin in Treating Patients With Liver Metastases From Colorectal Cancer	Completed	National Cancer Institute (NCI)	Phase 2	RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and giving drugs in different ways may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of surgery followed by floxuridine plus systemic fluorouracil and leucovorin in treating patients with liver metastases from colorectal cancer.
NCT00002842 ↗	Liver Resection and Floxuridine Plus Fluorouracil and Leucovorin in Treating Patients With Liver Metastases From Colorectal Cancer	Completed	City of Hope Medical Center	Phase 2	RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and giving drugs in different ways may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of surgery followed by floxuridine plus systemic fluorouracil and leucovorin in treating patients with liver metastases from colorectal cancer.
NCT00010023 ↗	Capecitabine Combined With Cisplatin in Treating Patients With Locally Advanced or Metastatic Solid Tumors	Completed	National Cancer Institute (NCI)	Phase 1	RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one chemotherapy drug may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of capecitabine combined with cisplatin in treating patients who have locally advanced or metastatic solid tumors .
NCT00010023 ↗	Capecitabine Combined With Cisplatin in Treating Patients With Locally Advanced or Metastatic Solid Tumors	Completed	New York University School of Medicine	Phase 1	RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one chemotherapy drug may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of capecitabine combined with cisplatin in treating patients who have locally advanced or metastatic solid tumors .
NCT00010023 ↗	Capecitabine Combined With Cisplatin in Treating Patients With Locally Advanced or Metastatic Solid Tumors	Completed	NYU Langone Health	Phase 1	RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one chemotherapy drug may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of capecitabine combined with cisplatin in treating patients who have locally advanced or metastatic solid tumors .
NCT00016250 ↗	Ro 31-7453 in Treating Patients With Recurrent or Refractory Metastatic Colorectal Cancer	Completed	National Cancer Institute (NCI)	Phase 2	RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Randomized phase II trial to compare the effectiveness of two different regimens of Ro 31-7453 in treating patients who have recurrent or refractory metastatic colorectal cancer.

Clinical Trial Conditions for Fluoropyrimidine

Condition Name

Condition Name
Intervention	Trials
Colorectal Cancer	46
Gastric Cancer	35
Metastatic Colorectal Cancer	29
Colorectal Neoplasms	15

Condition MeSH

Condition MeSH
Intervention	Trials
Colorectal Neoplasms	120
Stomach Neoplasms	73
Adenocarcinoma	54
Esophageal Neoplasms	33

Clinical Trial Locations for Fluoropyrimidine

Trials by Country

Trials by Country
Location	Trials
United States	569
Japan	213
China	124
Italy	89
Korea, Republic of	78

Trials by US State

Trials by US State
Location	Trials
California	42
New York	27
Pennsylvania	24
Texas	22
Illinois	22

Clinical Trial Progress for Fluoropyrimidine

Clinical Trial Phase

Clinical Trial Phase
Clinical Trial Phase	Trials
Phase 4	3
Phase 3	67
Phase 2/Phase 3	10

Clinical Trial Status

Clinical Trial Status
Clinical Trial Phase	Trials
Completed	127
Recruiting	67
Unknown status	42

Clinical Trial Sponsors for Fluoropyrimidine

Sponsor Name

Sponsor Name
Sponsor	Trials
National Cancer Institute (NCI)	20
Eli Lilly and Company	18
Hoffmann-La Roche	16

Sponsor Type

Sponsor Type
Sponsor	Trials
Other	369
Industry	194
NIH	20