CLINICAL TRIALS PROFILE FOR FOLIGLURAX

Clinical Trials for Foliglurax

Trial ID	Title	Status	Sponsor	Phase	Summary
NCT03162874 ↗	Study to Evaluate the Efficacy, Safety and Tolerability of PXT002331 (Foliglurax) in Reducing Motor Complications of Levodopa Therapy in Parkinson Disease's Patients	Completed	Prexton Therapeutics	Phase 2	This will be a double-blind, randomised, placebo-controlled parallel-arm phase II proof of concept in subjects with PD treated with a stable dose of levodopa who are experiencing both end-of-dose wearing off and Levodopa-Induced Dyskinesia (LID)
NCT03331848 ↗	Study to Evaluate the Efficacy, Safety, and Tolerability of PXT002331 (Foliglurax) in Reducing Levodopa-Induced Dyskinesia and Wearing OFF in Subjects With Parkinson's Disease Experiencing Motor Complications of Levodopa Therapy (ATTUNED)	Withdrawn	Prexton Therapeutics	Phase 2	This is a Multi-center, Double-blind, Randomized, Placebo-controlled, Parallel-arm Phase IIa proof of concept in subjects with PD treated with a stable dose of levodopa who are experiencing Motor Complications of Levodopa Therapy
NCT04002895 ↗	What the Body Does to Foliglurax in Healthy Volunteers	Completed	H. Lundbeck A/S	Phase 1	This study evaluates how the body takes up and gets rid of foliglurax after swallowing a liquid dose.
NCT04175132 ↗	Binding of Foliglurax to Regions in the Brain in Healthy Participants and in Patients With Parkinson's Disease (PD)	Terminated	H. Lundbeck A/S	Phase 1	A study to learn how foliglurax binds in regions of the brain
NCT04275115 ↗	Effects of Repeated Doses of Foliglurax on Drug Metabolizing Enzymes in Healthy Subjects	Completed	H. Lundbeck A/S	Phase 1	The purpose of this study is to help determine which types of drugs that may interact with foliglurax
NCT04322227 ↗	Study Investigating Effects of Foliglurax in Patients With Parkinson's Disease (PD) and Healthy Subjects	Terminated	H. Lundbeck A/S	Phase 1	The purpose of this study is to investigate effects of foliglurax on brain wave patterns (electric signals) in healthy subjects and in patients with PD

Clinical Trial Conditions for Foliglurax

Condition Name

Condition Name
Intervention	Trials
Healthy	4
Parkinson Disease	4

Condition MeSH

Condition MeSH
Intervention	Trials
Parkinson Disease	4
Dyskinesias	1

Clinical Trial Locations for Foliglurax

Trials by Country

Trials by Country
Location	Trials
France	3
United Kingdom	2
Spain	1
Austria	1
Italy	1

Clinical Trial Progress for Foliglurax

Clinical Trial Phase

Clinical Trial Phase
Clinical Trial Phase	Trials
Phase 2	2
Phase 1	4

Clinical Trial Status

Clinical Trial Status
Clinical Trial Phase	Trials
Completed	3
Terminated	2
Withdrawn	1

Clinical Trial Sponsors for Foliglurax

Sponsor Name

Sponsor Name
Sponsor	Trials
H. Lundbeck A/S	4
Prexton Therapeutics	2

Sponsor Type

Sponsor Type
Sponsor	Trials
Industry	6