CLINICAL TRIALS PROFILE FOR FOSMIDOMYCIN

Clinical Trials for Fosmidomycin

Trial ID	Title	Status	Sponsor	Phase	Summary
NCT00214643 ↗	Efficacy of Fosmidomycin-Clindamycin for Treating Malaria in Gabonese Children	Completed	Albert Schweitzer Hospital	Phase 3	There is a necessity for the development of new malaria drugs. Some antibiotics are also effective against malaria parasites. Fosmidomycin is an antibiotic that has been shown to be effective against malaria, although it cannot achieve a total cure in all patients. Previous small studies have shown that in combination with clindamycin, an commonly used antibiotic, it is highly effective and safe when given for three days, leading to a total cure in most patients. The current study will evaluate its efficacy in a larger population in Gabon, and compare its effect with the generally used drug, sulfadoxine-pyrimethamine.
NCT00217451 ↗	Treatment of Malaria in Gabon With Fosmidomycin-Clindamycin	Completed	Albert Schweitzer Hospital	Phase 2	Some antibiotics are also effective against malaria parasites. Fosmidomycin is an antibiotic that has been shown to be effective against malaria, although it cannot achieve a total cure in all patients. A previous small study has shown that in combination with clindamycin, an commonly used antibiotic, it is highly effective and safe, in asymptomatic carriers of malaria parasites. The current study will evaluate the efficacy and safety of the combination given for three days in children with uncomplicated malaria in Gabon.
NCT01002183 ↗	Fosmidomycin With Clindamycin or With Clindamycin Plus Artesunate	Withdrawn	Mahidol University	Phase 2	The aim of this study is to evaluate the role of clindamycin and artesunate as possible combination partners for fosmidomycin to protect it from its susceptibility to recrudescent infections when used as monotherapy for acute Plasmodium falciparum malaria while retaining its excellent safety profile
NCT01002183 ↗	Fosmidomycin With Clindamycin or With Clindamycin Plus Artesunate	Withdrawn	Thammasat University	Phase 2	The aim of this study is to evaluate the role of clindamycin and artesunate as possible combination partners for fosmidomycin to protect it from its susceptibility to recrudescent infections when used as monotherapy for acute Plasmodium falciparum malaria while retaining its excellent safety profile
NCT01002183 ↗	Fosmidomycin With Clindamycin or With Clindamycin Plus Artesunate	Withdrawn	Jomaa Pharma GmbH	Phase 2	The aim of this study is to evaluate the role of clindamycin and artesunate as possible combination partners for fosmidomycin to protect it from its susceptibility to recrudescent infections when used as monotherapy for acute Plasmodium falciparum malaria while retaining its excellent safety profile
NCT01361269 ↗	Evaluation of Fosmidomycin and Clindamycin in the Treatment of Acute Uncomplicated Plasmodium Falciparum Malaria	Unknown status	Albert Schweitzer Hospital	Phase 2	Few efficient drugs for malaria treatment are available so far. Due to increased exposure of these drugs and due to the high risk of development of drug resistant strains of Plasmodium falciparum, new drug combinations have to be actively investigated. The investigators will test the efficiency, safety and tolerance of combined fosmidomycin and clindamycin treatment in acute uncomplicated malaria in children aged 3-10 years.
NCT01361269 ↗	Evaluation of Fosmidomycin and Clindamycin in the Treatment of Acute Uncomplicated Plasmodium Falciparum Malaria	Unknown status	Centro de Investigacao em Saude de Manhica	Phase 2	Few efficient drugs for malaria treatment are available so far. Due to increased exposure of these drugs and due to the high risk of development of drug resistant strains of Plasmodium falciparum, new drug combinations have to be actively investigated. The investigators will test the efficiency, safety and tolerance of combined fosmidomycin and clindamycin treatment in acute uncomplicated malaria in children aged 3-10 years.

Clinical Trial Conditions for Fosmidomycin

Condition Name

Condition Name
Intervention	Trials
Malaria	6
Oral Treatment of Acute Uncomplicated Plasmodium Falciparum Malaria	1

Condition MeSH

Condition MeSH
Intervention	Trials
Malaria	7
Malaria, Falciparum	4

Clinical Trial Locations for Fosmidomycin

Trials by Country

Trials by Country
Location	Trials
Gabon	3
Thailand	2
Mozambique	1

Clinical Trial Progress for Fosmidomycin

Clinical Trial Phase

Clinical Trial Phase
Clinical Trial Phase	Trials
Phase 3	1
Phase 2	6

Clinical Trial Status

Clinical Trial Status
Clinical Trial Phase	Trials
Completed	3
Unknown status	3
Withdrawn	1

Clinical Trial Sponsors for Fosmidomycin

Sponsor Name

Sponsor Name
Sponsor	Trials
Jomaa Pharma GmbH	4
Albert Schweitzer Hospital	3
Thammasat University	2

Sponsor Type

Sponsor Type
Sponsor	Trials
Other	12
Industry	5