IMG-7289, With and Without ATRA, in Patients With Advanced Myeloid Malignancies
Completed
Imago BioSciences,Inc.
Phase 1
This is a Phase 1 open label study of the dose and duration of an orally administered LSD1
inhibitor, IMG-7289, in patients with acute myeloid leukemia (AML) and myelodysplastic
syndrome (MDS). Some participants may also receive all-trans retinoic acid (ATRA; also known
as tretinoin and Vesanoid®) in combination with IMG-7289. This study investigates the
following:
- The safety and tolerability of IMG-7289, with and without ATRA
- The pharmacodynamic effect of different IMG-7289 doses and treatment durations, as well
as IMG-7289 administered in combination with ATRA
- The pharmacokinetics of IMG-2789, with and without ATRA
This is a Phase 2b open label study of an orally administered LSD1 inhibitor, IMG-7289, in
patients with myelofibrosis.
This study investigates the following:
- The safety and tolerability of IMG-7289
- The pharmacokinetics of IMG-7289 (performed in Phase 1/2a only)
- The pharmacodynamic effect of IMG-7289
This is a single-center, open-label investigator-initiated trial evaluating the effects of
IMG-7289 administered orally once daily in patients with essential thrombocythemia.
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