CLINICAL TRIALS PROFILE FOR IMR-687

Clinical Trials for IMR-687

Trial ID	Title	Status	Sponsor	Phase	Summary
NCT02998450 ↗	A Study of IMR-687 in Healthy Adult Volunteers	Completed	Quintiles, Inc.	Phase 1	The purpose of this Phase 1a, first in human, randomized, double-blind, placebo-controlled study is to evaluate the safety, tolerability, PK and PD profile of the orally administered IMR-687 in healthy adult subjects.
NCT02998450 ↗	A Study of IMR-687 in Healthy Adult Volunteers	Completed	Imara, Inc.	Phase 1	The purpose of this Phase 1a, first in human, randomized, double-blind, placebo-controlled study is to evaluate the safety, tolerability, PK and PD profile of the orally administered IMR-687 in healthy adult subjects.
NCT03401112 ↗	A Study of IMR-687 in Adult Patients With Sickle Cell Anaemia (Homozygous HbSS or Sickle-β0 Thalassemia)	Completed	Imara, Inc.	Phase 2	A Phase 2a, Randomised, Double-Blind, Placebo-Controlled Study of IMR-687 in Adult Patients with Sickle Cell Anaemia (Homozygous HbSS or Sickle-β0 Thalassemia).
NCT04053803 ↗	An Extension Study of IMR-687 in Adult Patients With Sickle Cell Anemia	Enrolling by invitation	Imara, Inc.	Phase 2	This is an open-label extension study of IMR-687 in adult patients who completed Imara's blinded Phase 2a study (IMR-SCD-102). The open-label extension study will evaluate long-term safety and tolerability.
NCT04411082 ↗	A Study of IMR-687 in Subjects With Beta Thalassemia	Recruiting	Imara, Inc.	Phase 2	A Study to Evaluate the Safety and Tolerability of IMR-687 in Subjects with Beta Thalassemia

Clinical Trial Conditions for IMR-687

Condition Name

Condition Name
Intervention	Trials
Sickle Cell Disease	4
Heart Failure With Preserved Ejection Fraction	1
Sickle Beta 0 Thalassemia	1
Sickle-Cell; Hb-SC	1

Condition MeSH

Condition MeSH
Intervention	Trials
Anemia, Sickle Cell	4
Thalassemia	3
Heart Failure	1
beta-Thalassemia	1

Clinical Trial Locations for IMR-687

Trials by Country

Trials by Country
Location	Trials
United States	28
Malaysia	6
Italy	6
Greece	5
United Kingdom	4

Trials by US State

Trials by US State
Location	Trials
Texas	3
Connecticut	3
California	3
New York	2
Illinois	2

Clinical Trial Progress for IMR-687

Clinical Trial Phase

Clinical Trial Phase
Clinical Trial Phase	Trials
Phase 2	5
Phase 1	1

Clinical Trial Status

Clinical Trial Status
Clinical Trial Phase	Trials
Completed	2
Not yet recruiting	1
Active, not recruiting	1

Clinical Trial Sponsors for IMR-687

Sponsor Name

Sponsor Name
Sponsor	Trials
Imara, Inc.	6
Quintiles, Inc.	1

Sponsor Type

Sponsor Type
Sponsor	Trials
Industry	7