A Randomized, Double-Blind, Placebo Controlled Study of l-Leucovorin in Combination With Trimethoprim / Sulfamethoxazole in the Therapy of Pneumocystis Carinii Pneumonia in Patients With the Acquired Immunodeficiency Syndrome
Completed
Lederle Laboratories
N/A
The primary objective of the study is to evaluate the effectiveness of l-leucovorin in
preventing toxicity from high dose trimethoprim / sulfamethoxazole (TMP / SMX) used as a
therapy for Pneumocystis carinii pneumonia (PCP) in patients with AIDS.
Leucovorin and Fluorouracil Compared With Observation in Treating Patients With Colorectal Cancer That Has Been Surgically Removed
Completed
Institute of Cancer Research, United Kingdom
Phase 3
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. Combining more than one drug may kill more tumor cells. It is not
yet known whether chemotherapy is more effective than observation in patients who have had
surgery to remove colorectal cancer.
PURPOSE: This randomized phase III trial is studying leucovorin and fluorouracil to see how
well they work compared to observation in treating patients with colorectal cancer that has
been surgically removed.
Combination Chemotherapy in Treating Patients With Colon Cancer
Unknown status
Groupe Regional d'Etudes du Cancer Colorectal
Phase 3
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. It is not yet known which schedule of chemotherapy is most
effective in treating colon cancer.
PURPOSE: Randomized phase III trial to compare different schedules of chemotherapy using
carboplatin with fluorouracil and leucovorin in treating patients who have stage IIB or stage
III colon cancer.
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