A Study to Evaluate the Effects of 3 Months Dosing With GW856553, as Assessed FDG-PET/CT Imaging
Completed
GlaxoSmithKline
Phase 2
This study is being conducted to assess the potential anti-inflammatory effects of a 3-month
treatment with GW856553, on the inflammatory activity within the aorta and carotid plaques,
as assessed by FDG-PET/CT.
Randomised, Double-Blind, Placebo-Controlled, Parallel-Group, Multi-centre, Dose Ranging Study to Evaluate the Efficacy and Safety of Losmapimod Tablets Administered Twice Daily Compared With Placebo for 24 Weeks in Adult Subjects With Chronic Obstr
Completed
GlaxoSmithKline
Phase 2
Randomised, double-blind, parallel-group, multi-centre study evaluating three doses of
losmapimod (2.5mg, 7.5 mg and 15 mg) twice daily (BID) versus placebo on exercise tolerance.
Eligible subjects will be randomised to treatment after a one-week run-in period. The
duration of the treatment period is 24 weeks. An estimated 1000 subjects will be screened to
reach the target enrolment of approximately 600 randomised subjects.
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