First In Human, Single Escalating Oral Dose Study Of PF-06882961 In Healthy Adult Subjects
Completed
Pfizer
Phase 1
The purpose of this study is to evaluate the safety, tolerability and pharmacokinetics of
single oral doses of PF-06882961 in healthy adult subjects. This is the first clinical study
of PF-06882961.
A Single Dose Crossover Study In Healthy Subjects To Evaluate Different Formulations Of PF-06882961
Completed
Pfizer
Phase 1
This open label study will evaluate the pharmacokinetics (PK) following single oral doses of
different formulations of PF-06882961, including controlled release (CR) tablets at 2 release
rates (long and short duration), an immediate release (IR) oral solution, and IR tablets, in
healthy adult subjects.
4-Week, Multiple-dose, Dose-escalating Study In Patients With Type 2 Diabetes
Completed
Pfizer
Phase 1
This is a dose-escalating study in patients with Type 2 diabetes on metformin. Participants
will receive an investigational product or placebo for 28 days.
A 16 Week Study to Evaluate the Efficacy and Safety of PF-06882961 in Adults With Type 2 Diabetes Mellitus
Completed
Pfizer
Phase 2
This multicenter, randomized, double-blind, placebo controlled, parallel group study is being
conducted to provide data on efficacy, safety, tolerability and pharmacokinetics (PK) of
multiple dose levels of PF-06882961 in adults with type 2 diabetes mellitus (T2DM)
inadequately controlled on metformin and/or diet and exercise. In addition, the study is
intended to enable selection of efficacious doses for future clinical development of
PF-06882961.
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