A Phase 1/2, Open-Label, Dose Escalation, Safety and Tolerability Study of INCB050465 and Itacitinib in Subjects With Previously Treated B-Cell Malignancies (CITADEL-101)
Completed
Incyte Corporation
Phase 1/Phase 2
Open-label, dose-escalation study in subjects with previously treated B-cell malignancies to
find maximum tolerated dose (MTD) or pharmacologic active dose of a PI3Kδ inhibitor,
parsaclisib, as monotherapy and in combination with: itacitinib (INCB039110), a JAK1
inhibitor; rituximab; and rituximab, ifosfamide, carboplatin, and etoposide. Parsaclisib
inhibits PI3Kδ, a protein involved in growth and survival of B-cell cancer cells.
A Study of INCB050465 in Combination With Ruxolitinib in Subjects With Myelofibrosis
Active, not recruiting
Incyte Corporation
Phase 2
The purpose of this study is to evaluate the safety, tolerability, and efficacy of the
combination of parsaclisib and ruxolitinib in subjects with myelofibrosis.
Study Evaluating Safety and Efficacy of INCB050465 Combined With Bendamustine and Obinutuzumab in Relapsed or Refractory Follicular Lymphoma (CITADEL-102)
Active, not recruiting
Incyte Corporation
Phase 1
The purpose of this study is to evaluate the safety and efficacy of parsaclisib when combined
with bendamustine and obinutuzumab in subjects with relapsed or refractory follicular
lymphoma (FL).
An Open-Label Study of INCB050465 in Relapsed or Refractory Follicular Lymphoma (CITADEL-203)
Active, not recruiting
Incyte Corporation
Phase 2
The purpose of this study is to assess the objective response rate of parsaclisib treatment
in subjects with relapsed or refractory follicular lymphoma.
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