CLINICAL TRIALS PROFILE FOR TEW-7197

Clinical Trials for TEW-7197

Trial ID	Title	Status	Sponsor	Phase	Summary
NCT02160106 ↗	First in Human Dose Escalation Study of Vactosertib (TEW-7197) in Subjects With Advanced Stage Solid Tumors	Completed	National OncoVenture	Phase 1	The phase I dose escalation study will investigate the safety, tolerability, and pharmacokinetics of the TGF-β pathway inhibitor TEW 7197 in subjects with advanced, refractory solid tumors.
NCT02160106 ↗	First in Human Dose Escalation Study of Vactosertib (TEW-7197) in Subjects With Advanced Stage Solid Tumors	Completed	MedPacto, Inc.	Phase 1	The phase I dose escalation study will investigate the safety, tolerability, and pharmacokinetics of the TGF-β pathway inhibitor TEW 7197 in subjects with advanced, refractory solid tumors.
NCT03074006 ↗	Dose Escalation and Proof-of-Concept Studies of Vactosertib (TEW-7197) Monotherapy in Patients With MDS	Completed	MedPacto, Inc.	Phase 1	This is a prospective, open-label, multicenter, phase 1/2 study of TEW-7197 in patients with low and intermediate risk of myelodysplastic syndrome (MDS).
NCT03143985 ↗	Vactosertib in Combination w/ Pomalidomide in Relapsed or Relapsed and Refractory Multiple Myeloma	Recruiting	Case Comprehensive Cancer Center	Phase 1	The purpose of this study is to see if the study drug, called Vactosertib, is safe and determine what the best dose is to treat future patients when given in combination with pomalidomide (POM). The study will also look to see if it has any effect on multiple myeloma, when given in combination with POM.

Clinical Trial Conditions for TEW-7197

Condition Name

Condition Name
Intervention	Trials
Myelodysplastic Syndromes	2
Gastric Cancer	2
Chronic Myeloid Leukemia	1
Multiple Myeloma	1

Condition MeSH

Condition MeSH
Intervention	Trials
Adenocarcinoma	4
Syndrome	2
Colorectal Neoplasms	2
Stomach Neoplasms	2

Clinical Trial Locations for TEW-7197

Trials by Country

Trials by Country
Location	Trials
United States	10
Korea, Republic of	7

Trials by US State

Trials by US State
Location	Trials
New York	3
Ohio	2
California	1
Maryland	1
Florida	1

Clinical Trial Progress for TEW-7197

Clinical Trial Phase

Clinical Trial Phase
Clinical Trial Phase	Trials
Phase 2	3
Phase 1/Phase 2	6
Phase 1	6

Clinical Trial Status

Clinical Trial Status
Clinical Trial Phase	Trials
Not yet recruiting	5
Recruiting	4
Active, not recruiting	3

Clinical Trial Sponsors for TEW-7197

Sponsor Name

Sponsor Name
Sponsor	Trials
MedPacto, Inc.	8
Samsung Medical Center	2
AstraZeneca	2

Sponsor Type

Sponsor Type
Sponsor	Trials
Industry	11
Other	9