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Last Updated: July 16, 2024

CLINICAL TRIALS PROFILE FOR TALAPORFIN

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Clinical Trials for Talaporfin

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Trial ID	Title	Status	Sponsor	Phase	Summary
NCT00068068 ↗	Photodynamic Therapy With Talaporfin Sodium (LS11) in Treating Patients With Refractory Colorectal Liver Metastases	Completed	Light Sciences LLC	Phase 2	The purpose of this study is to determine whether the Litx platform is safe and effective in the treatment of liver metastasis arising from colorectal cancer. Litx is a next-generation photodynamic therapy platform in which the drug, talaporfin sodium (LS11), is activated by light from the light-emitting diode (LED)-based light infusion device, inserted directly into the tumor through the skin prior to treatment.
NCT00083785 ↗	Study of the Litx™ System Combined With Chemotherapy in Patients With Colorectal Liver Metastases	Completed	Light Sciences LLC	Phase 2	The purpose of this study is to determine whether the Litx™ system is safe and effective in combination with chemotherapy in the treatment of liver metastasis arising from colorectal cancer. Litx™ is a next-generation photodynamic therapy platform in which the drug, talaporfin sodium (LS11), is activated by light from the light-emitting diode (LED)-based light infusion device, inserted directly into the tumor through the skin prior to treatment.
NCT00102115 ↗	Study of Talaporfin Sodium Photodynamic Therapy to Treat Advanced Age Related Macular Disease	Terminated	Light Sciences LLC	Phase 1	The purpose of this study is to determine the safety and tolerability of Talaporfin Sodium (LS11) Photodynamic Therapy in patients with late stage Age-Related Macular Disease (AMD).
NCT00122876 ↗	Tumor Ablation With Talaporfin Sodium and Interstitial Light Emitting Diodes Treating Hepatocellular Carcinoma (HCC)	Completed	Light Sciences Oncology	Phase 1/Phase 2	The purpose of this study is to determine whether the Litx™ treatment is safe and effective in treating inoperable hepatocellular carcinoma (HCC). Litx™ is an integrated treatment system comprising an intravenously administered photosensitizing agent, Talaporfin Sodium (LS11), that is activated by non-coherent light generated inside the tumor by an implanted light emitting diode (LED) array light source.
>Trial ID	>Title	>Status	>Sponsor	>Phase	>Summary

Clinical Trial Conditions for Talaporfin

Condition Name

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Condition Name
Intervention	Trials
Liver Neoplasms	4
Benign Prostatic Hyperplasia	3
Neoplasm Metastasis	3
Colorectal Neoplasms	3
[disabled in preview]	0
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Condition MeSH

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Condition MeSH
Intervention	Trials
Liver Neoplasms	5
Hyperplasia	3
Neoplasm Metastasis	3
Colorectal Neoplasms	3
[disabled in preview]	0
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Clinical Trial Locations for Talaporfin

Trials by Country

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Trials by Country
Location	Trials
United States	35
India	4
Hong Kong	3
Serbia	3
Poland	2
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Trials by US State

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Trials by US State
Location	Trials
Washington	4
California	3
Texas	3
Pennsylvania	3
Oregon	2
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Clinical Trial Progress for Talaporfin

Clinical Trial Phase

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Clinical Trial Phase
Clinical Trial Phase	Trials
Phase 3	2
Phase 2	5
Phase 1/Phase 2	1
[disabled in preview]	4
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Clinical Trial Status

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Clinical Trial Status
Clinical Trial Phase	Trials
Completed	10
Terminated	2
[disabled in preview]	0
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Clinical Trial Sponsors for Talaporfin

Sponsor Name

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Sponsor Name
Sponsor	Trials
Light Sciences Oncology	7
Light Sciences LLC	3
United States Department of Defense	1
[disabled in preview]	1
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Sponsor Type

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Sponsor Type
Sponsor	Trials
Industry	11
Other	3
U.S. Fed	1
[disabled in preview]	0
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