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Last Updated: April 9, 2025

CLINICAL TRIALS PROFILE FOR TIPIFARNIB

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Clinical Trials for Tipifarnib

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Trial ID	Title	Status	Sponsor	Phase	Summary

NCT00003707 ↗	Combination Chemotherapy in Treating Patients With Advanced Cancer	Completed	National Cancer Institute (NCI)	Phase 1	RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. PURPOSE: Phase I trial to study the effectiveness of combining R115777 with gemcitabine in treating patients with advanced cancer.
NCT00003707 ↗	Combination Chemotherapy in Treating Patients With Advanced Cancer	Completed	The University of Texas Health Science Center at San Antonio	Phase 1	RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. PURPOSE: Phase I trial to study the effectiveness of combining R115777 with gemcitabine in treating patients with advanced cancer.
NCT00004009 ↗	R115777 in Treating Patients With Refractory or Recurrent Acute Leukemia or Chronic Myelogenous Leukemia	Completed	National Cancer Institute (NCI)	Phase 1	RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of R115777 in treating patients who have refractory or recurrent acute leukemia or chronic myelogenous leukemia.
NCT00004009 ↗	R115777 in Treating Patients With Refractory or Recurrent Acute Leukemia or Chronic Myelogenous Leukemia	Completed	University of Maryland Greenebaum Cancer Center	Phase 1	RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of R115777 in treating patients who have refractory or recurrent acute leukemia or chronic myelogenous leukemia.
NCT00004009 ↗	R115777 in Treating Patients With Refractory or Recurrent Acute Leukemia or Chronic Myelogenous Leukemia	Completed	University of Maryland, Baltimore	Phase 1	RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of R115777 in treating patients who have refractory or recurrent acute leukemia or chronic myelogenous leukemia.
NCT00005041 ↗	R115777 in Treating Patients With Relapsed Small Cell Lung Cancer	Completed	National Cancer Institute (NCI)	Phase 2	RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of R115777 in treating patients who have relapsed small cell lung cancer.
>Trial ID	>Title	>Status	>Sponsor	>Phase	>Summary

Showing 1 to 6 of 6 entries

Clinical Trial Conditions for Tipifarnib

Condition Name

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Condition Name
Intervention	Trials
Untreated Adult Acute Myeloid Leukemia	8
Leukemia	8
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities	7
Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)	7
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Condition MeSH

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Condition MeSH
Intervention	Trials
Leukemia	27
Leukemia, Myeloid	22
Leukemia, Myeloid, Acute	19
Leukemia, Myelomonocytic, Acute	13
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Clinical Trial Locations for Tipifarnib

Trials by Country

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Trials by Country
Location	Trials
United States	356
Spain	15
United Kingdom	8
Canada	6
Germany	6
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Trials by US State

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Trials by US State
Location	Trials
California	22
New York	22
Texas	22
Florida	18
Maryland	17
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Clinical Trial Progress for Tipifarnib

Clinical Trial Phase

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Clinical Trial Phase
Clinical Trial Phase	Trials
Phase 3	3
Phase 2/Phase 3	1
Phase 2	46
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Clinical Trial Status

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Clinical Trial Status
Clinical Trial Phase	Trials
Completed	68
Recruiting	8
Terminated	5
[disabled in preview]	4
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Clinical Trial Sponsors for Tipifarnib

Sponsor Name

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Sponsor Name
Sponsor	Trials
National Cancer Institute (NCI)	63
Kura Oncology, Inc.	8
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	7
[disabled in preview]	6
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Sponsor Type

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Sponsor Type
Sponsor	Trials
NIH	65
Other	39
Industry	21
[disabled in preview]	0
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