CLINICAL TRIALS PROFILE FOR TRIAPINE

Clinical Trials for Triapine

Trial ID	Title	Status	Sponsor	Phase	Summary
NCT00004213 ↗	3-Aminopyridine-2-carboxaldehyde Thiosemicarbazone in Treating Patients With Solid Tumors	Completed	Vion Pharmaceuticals	Phase 1	RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone in treating patients who have solid tumors that have not responded to previous treatment.
NCT00006218 ↗	3-AP in Treating Patients With Advanced Cancer	Completed	Vion Pharmaceuticals	Phase 1	RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of 3-AP in treating patients who have advanced cancer.
NCT00016874 ↗	3-AP Plus Cisplatin and Paclitaxel in Treating Patients With Advanced or Metastatic Cancer	Completed	Vion Pharmaceuticals	Phase 1	RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of combining 3-AP, cisplatin, and paclitaxel in treating patients who have advanced or metastatic cancer.
NCT00024323 ↗	Combination Chemotherapy in Treating Patients With Advanced Cancer	Completed	Vion Pharmaceuticals	Phase 1	RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of combining 3-AP with cisplatin in treating patients who have advanced cancer.
NCT00054015 ↗	3-AP in Treating Patients With Advanced Prostate Cancer	Completed	Vion Pharmaceuticals	Phase 2	RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of 3-AP in treating patients who have advanced prostate cancer that has been previously treated with hormone therapy.
NCT00064051 ↗	3-AP and Gemcitabine in Treating Patients With Unresectable or Metastatic Pancreatic Cancer	Completed	Vion Pharmaceuticals	Phase 2	RATIONALE: Drugs used in chemotherapy such as gemcitabine use different ways to stop tumor cells from dividing so they stop growing or die. 3-AP may stop the growth of tumor cells by blocking the enzymes necessary for tumor cell growth and may help gemcitabine kill more cancer cells by making them more sensitive to the drug. PURPOSE: This phase II trial is studying how well giving gemcitabine together with 3-AP works in treating patients with unresectable or metastatic pancreatic cancer.
NCT00064064 ↗	3-AP and Gemcitabine in Treating Patients With Metastatic Non-Small Cell Lung Cancer	Completed	Vion Pharmaceuticals	Phase 2	RATIONALE: Drugs used in chemotherapy such as gemcitabine use different ways to stop tumor cells from dividing so they stop growing or die. 3-AP may stop the growth of tumor cells by blocking the enzymes necessary for tumor cell growth and may help gemcitabine kill more cancer cells by making them more sensitive to the drug. PURPOSE: Phase II trial to study the effectiveness of combining gemcitabine with 3-AP in treating patients who have metastatic non-small cell lung cancer.

Clinical Trial Conditions for Triapine

Condition Name

Condition Name
Intervention	Trials
Unspecified Adult Solid Tumor, Protocol Specific	8
Stage IVA Cervical Cancer	5
Stage IVA Vaginal Cancer	4
Stage IIIB Cervical Cancer	4

Condition MeSH

Condition MeSH
Intervention	Trials
Adenocarcinoma	7
Uterine Cervical Neoplasms	5
Leukemia	5
Vaginal Neoplasms	5

Clinical Trial Locations for Triapine

Trials by Country

Trials by Country
Location	Trials
United States	141
Canada	6
Puerto Rico	2
Australia	2
Netherlands	1

Trials by US State

Trials by US State
Location	Trials
Illinois	7
Ohio	7
Minnesota	7
California	6
Pennsylvania	6

Clinical Trial Progress for Triapine

Clinical Trial Phase

Clinical Trial Phase
Clinical Trial Phase	Trials
Phase 3	2
Phase 2	15
Phase 1	15

Clinical Trial Status

Clinical Trial Status
Clinical Trial Phase	Trials
Completed	26
Recruiting	5
Not yet recruiting	1

Clinical Trial Sponsors for Triapine

Sponsor Name

Sponsor Name
Sponsor	Trials
National Cancer Institute (NCI)	25
Vion Pharmaceuticals	8
NRG Oncology	2

Sponsor Type

Sponsor Type
Sponsor	Trials
NIH	25
Industry	8
Other	7