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Last Updated: December 11, 2024

CLINICAL TRIALS PROFILE FOR VACTOSERTIB

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Clinical Trials for Vactosertib

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Trial ID	Title	Status	Sponsor	Phase	Summary
NCT02160106 ↗	First in Human Dose Escalation Study of Vactosertib (TEW-7197) in Subjects With Advanced Stage Solid Tumors	Completed	National OncoVenture	Phase 1	The phase I dose escalation study will investigate the safety, tolerability, and pharmacokinetics of the TGF-β pathway inhibitor TEW 7197 in subjects with advanced, refractory solid tumors.
NCT02160106 ↗	First in Human Dose Escalation Study of Vactosertib (TEW-7197) in Subjects With Advanced Stage Solid Tumors	Completed	MedPacto, Inc.	Phase 1	The phase I dose escalation study will investigate the safety, tolerability, and pharmacokinetics of the TGF-β pathway inhibitor TEW 7197 in subjects with advanced, refractory solid tumors.
NCT03074006 ↗	Dose Escalation and Proof-of-Concept Studies of Vactosertib (TEW-7197) Monotherapy in Patients With MDS	Completed	MedPacto, Inc.	Phase 1	This is a prospective, open-label, multicenter, phase 1/2 study of TEW-7197 in patients with low and intermediate risk of myelodysplastic syndrome (MDS).
>Trial ID	>Title	>Status	>Sponsor	>Phase	>Summary

Clinical Trial Conditions for Vactosertib

Condition Name

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Condition Name
Intervention	Trials
Myelodysplastic Syndromes	2
Gastric Cancer	2
Stage IV Colorectal Cancer AJCC v8	1
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Condition MeSH

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Condition MeSH
Intervention	Trials
Colorectal Neoplasms	3
Adenocarcinoma	3
Neoplasms	3
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Clinical Trial Locations for Vactosertib

Trials by Country

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Trials by Country
Location	Trials
United States	11
Korea, Republic of	8
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Trials by US State

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Trials by US State
Location	Trials
New York	3
California	2
Ohio	2
Maryland	1
Florida	1
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Clinical Trial Progress for Vactosertib

Clinical Trial Phase

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Clinical Trial Phase
Clinical Trial Phase	Trials
Phase 2	7
Phase 1/Phase 2	5
Phase 1	6
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Clinical Trial Status

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Clinical Trial Status
Clinical Trial Phase	Trials
Not yet recruiting	7
Recruiting	5
Completed	3
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Clinical Trial Sponsors for Vactosertib

Sponsor Name

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Sponsor Name
Sponsor	Trials
MedPacto, Inc.	10
Merck Sharp & Dohme Corp.	2
AstraZeneca	2
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Sponsor Type

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Sponsor Type
Sponsor	Trials
Industry	14
Other	12
NIH	1
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