CLINICAL TRIALS PROFILE FOR VOLIXIBAT

Clinical Trials for Volixibat

Trial ID	Title	Status	Sponsor	Phase	Summary
NCT02475317 ↗	Study to Assess the Relative Potency of Multiple Oral Doses of LUM001 and SHP626 in Overweight and Obese Adults as Assessed by Fecal Bile Acid Excretion	Completed	Mirum Pharmaceuticals, Inc.	Phase 1	The purpose of this study is to assess the relative potency of multiple oral doses of LUM001 and SHP626 administered for 7 days as assessed by fecal bile acid excretion in overweight and obese adult subjects. This study is designed to address the relative potency question for the first time in the same.
NCT02475317 ↗	Study to Assess the Relative Potency of Multiple Oral Doses of LUM001 and SHP626 in Overweight and Obese Adults as Assessed by Fecal Bile Acid Excretion	Completed	Shire	Phase 1	The purpose of this study is to assess the relative potency of multiple oral doses of LUM001 and SHP626 administered for 7 days as assessed by fecal bile acid excretion in overweight and obese adult subjects. This study is designed to address the relative potency question for the first time in the same.
NCT02787304 ↗	Volixibat (SHP626) in the Treatment of Adults With Nonalcoholic Steatohepatitis (NASH)	Terminated	Mirum Pharmaceuticals, Inc.	Phase 2	The purpose of this study is to determine if the investigational treatment volixibat (SHP626) is safe, tolerable and effective in adults with nonalcoholic steatohepatitis (NASH).

Clinical Trial Conditions for Volixibat

Condition Name

Condition Name
Intervention	Trials
Primary Biliary Cholangitis	1
Primary Sclerosing Cholangitis	1
Healthy Volunteers	1

Condition MeSH

Condition MeSH
Intervention	Trials
Cholangitis	2
Cholestasis, Intrahepatic	1
Cholestasis	1

Clinical Trial Locations for Volixibat

Trials by Country

Trials by Country
Location	Trials
United States	47
United Kingdom	8
Canada	5
New Zealand	2
Puerto Rico	1

Trials by US State

Trials by US State
Location	Trials
Mississippi	3
Florida	3
California	3
Tennessee	3
Texas	3

Clinical Trial Progress for Volixibat

Clinical Trial Phase

Clinical Trial Phase
Clinical Trial Phase	Trials
Phase 2	4
Phase 1	1

Clinical Trial Status

Clinical Trial Status
Clinical Trial Phase	Trials
Recruiting	3
Terminated	1
Completed	1

Clinical Trial Sponsors for Volixibat

Sponsor Name

Sponsor Name
Sponsor	Trials
Mirum Pharmaceuticals, Inc.	5
Shire	2

Sponsor Type

Sponsor Type
Sponsor	Trials
Industry	7