This is a Phase 3 randomized, parallel-group, double-blind, placebo-controlled trial (Blinded
Treatment Period) followed by an Open-Label Extension Period intended to evaluate the
efficacy and safety of oral PRN1008 in moderate to severe pemphigus. After completing the
Open-Label Extension Period, eligible patients may continue in a Long Term Extension Period
of 48 weeks.
This is a Phase 3 randomized, parallel-group, double-blind, placebo-controlled trial (Blinded
Treatment Period) followed by an Open-Label Extension Period intended to evaluate the
efficacy and safety of oral PRN1008 in moderate to severe pemphigus. After completing the
Open-Label Extension Period, eligible patients may continue in a Long Term Extension Period
of 48 weeks.
Open Label Two-Arm Study to Evaluate Rilzabrutinib (PRN1008) in IgG4-Related Disease Patients
Recruiting
Massachusetts General Hospital
Phase 2
PRN1008-017 is a Phase 2a, multi-center, open-label, two-arm study of approximately 25
patients with active IgG4-related disease (IgG4-RD). The two arms include (1) Experimental:
PRN1008 with glucocorticoids and (2) Active Comparator: glucocorticoids only.
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