ASPIRIN; CAFFEINE; ORPHENADRINE CITRATE - Generic Drug Details

What are the generic drug sources for aspirin; caffeine; orphenadrine citrate and what is the scope of patent protection?

Aspirin; caffeine; orphenadrine citrate is the generic ingredient in seven branded drugs marketed by Sandoz, Bausch, Stevens J, and Galt Pharms, and is included in five NDAs. Additional information is available in the individual branded drug profile pages.

Four suppliers are listed for this compound.

Summary for ASPIRIN; CAFFEINE; ORPHENADRINE CITRATE

US Patents:	0
Tradenames:	7
Applicants:	4
NDAs:	5
Finished Product Suppliers / Packagers:	4
DailyMed Link:	ASPIRIN; CAFFEINE; ORPHENADRINE CITRATE at DailyMed

Pharmacology for ASPIRIN; CAFFEINE; ORPHENADRINE CITRATE

Drug Class	Central Nervous System Stimulant Methylxanthine Muscle Relaxant Nonsteroidal Anti-inflammatory Drug Platelet Aggregation Inhibitor
Mechanism of Action	Cyclooxygenase Inhibitors
Physiological Effect	Central Nervous System Stimulation Centrally-mediated Muscle Relaxation Decreased Platelet Aggregation Decreased Prostaglandin Production

Anatomical Therapeutic Chemical (ATC) Classes for ASPIRIN; CAFFEINE; ORPHENADRINE CITRATE

D11AX	Other dermatologicals
D11A	OTHER DERMATOLOGICAL PREPARATIONS
D11	OTHER DERMATOLOGICAL PREPARATIONS
D	Dermatologicals

N06BC	Xanthine derivatives
N06B	PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
N06	PSYCHOANALEPTICS
N	Nervous system

US Patents and Regulatory Information for ASPIRIN; CAFFEINE; ORPHENADRINE CITRATE

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
Bausch	NORGESIC FORTE	aspirin; caffeine; orphenadrine citrate	TABLET;ORAL	013416-004	Oct 27, 1982		DISCN	Yes	No
Sandoz	ORPHENADRINE CITRATE, ASPIRIN, AND CAFFEINE	aspirin; caffeine; orphenadrine citrate	TABLET;ORAL	074654-001	Dec 31, 1996		DISCN	No	No
Sandoz	INVAGESIC	aspirin; caffeine; orphenadrine citrate	TABLET;ORAL	074817-001	Nov 27, 1996		DISCN	No	No
Stevens J	ORPHENADRINE CITRATE, ASPIRIN, AND CAFFEINE	aspirin; caffeine; orphenadrine citrate	TABLET;ORAL	074988-001	Apr 30, 1999		DISCN	No	No
Galt Pharms	ORPHENGESIC	aspirin; caffeine; orphenadrine citrate	TABLET;ORAL	075141-001	May 29, 1998		RX	No	No
Bausch	NORGESIC	aspirin; caffeine; orphenadrine citrate	TABLET;ORAL	013416-003	Oct 27, 1982		DISCN	Yes	No

ASPIRIN; CAFFEINE; ORPHENADRINE CITRATE Market Analysis and Financial Projection Experimental

Market Dynamics and Financial Trajectory for Aspirin, Caffeine, and Orphenadrine Citrate

Aspirin Market Dynamics

Current Market Trends

The aspirin market has been experiencing significant growth driven by several key factors. In the third quarter of 2024, aspirin prices in various regions, including Asia, Europe, and North America, showed an upward trajectory. This increase was largely due to strong market fundamentals and supply chain disruptions[1].

Regional Price Trends

• Asia: The Asian market saw a notable increase in aspirin prices, driven by robust demand and tightening supply conditions. China, in particular, exhibited strong buying sentiment from the pharmaceutical sector, leading to firm pricing by suppliers[1].
• Europe: European aspirin prices also rose, influenced by increased buying activity from pharmaceutical manufacturers and the healthcare sector. Despite high logistics costs, sellers managed to implement price hikes due to favorable market dynamics[1].
• North America: The US market experienced steady price appreciation, driven by rising production costs and stable demand from end-user industries. Supply chain bottlenecks and raw material cost surges further accelerated price increases mid-quarter[1].

Future Outlook

Market analysts predict that aspirin prices will continue their upward momentum in the coming months, driven by sustained demand and persistent supply chain challenges. The global aspirin drug market is expected to grow from $2,938.2 million in 2024 to $4,236.9 million by 2034, with a CAGR of 3.8% over the next decade[5].

Drivers of Growth

• Cardiovascular Diseases: A surge in cardiovascular diseases, fueled by lifestyle factors such as high-cholesterol diets and smoking, is a significant driver of the aspirin market.
• Combination Aspirins: The dominance of combination aspirins, which include other active ingredients, is also driving market growth[5].

Caffeine Market Dynamics

While the sources provided do not specifically address the caffeine market, it is worth noting that caffeine is often used in combination with other drugs, including aspirin, to enhance their effects.

Combination Products

Caffeine is commonly found in combination products, such as aspirin and caffeine tablets, which are used to treat headaches and other pain conditions. The demand for these combination products can influence the overall market dynamics of both aspirin and caffeine.

Orphenadrine Citrate Market Dynamics

Current Market Trends

The Orphenadrine Citrate market is poised for substantial growth, driven by several key factors.

Drivers of Growth

• Musculoskeletal Disorders: The increasing prevalence of musculoskeletal disorders and chronic pain conditions is driving the demand for Orphenadrine Citrate[2].
• Non-Opioid Alternatives: The trend towards non-opioid pain management solutions is gaining momentum, as healthcare providers seek to minimize the risks associated with opioid use[2].
• Advancements in Formulations: Ongoing research and development efforts are leading to improved formulations and potential new indications for Orphenadrine Citrate, broadening its application scope[2].

Regional Growth

• Asia-Pacific: This region is rapidly growing, driven by countries such as China, Japan, India, and South Korea, due to a large population, rising disposable income, and increasing urbanization[2].
• Europe: Europe is characterized by a mature market with well-established infrastructure and consumer preferences. Countries like the UK, Germany, France, and Italy are key players in this region[2].
• Latin America and Middle East & Africa: These regions present opportunities and challenges, with economic fluctuations and political instability in some countries impacting market dynamics[2].

Future Outlook

The Orphenadrine Citrate market is anticipated to grow at a CAGR of 11.46% from 2024 to 2031, transitioning from a valuation of USD 24.57 billion in 2024 to USD 52.51 billion by 2031. This growth is expected to be driven by the increasing incidence of chronic pain conditions, advancements in pharmaceutical formulations, and the growing focus on non-opioid alternatives[2].

Financial Trajectory

Aspirin

• The global aspirin drug market is projected to grow from $2,938.2 million in 2024 to $4,236.9 million by 2034, with a CAGR of 3.8%[5].

Orphenadrine Citrate

• The Orphenadrine Citrate market is expected to grow from USD 24.57 billion in 2024 to USD 52.51 billion by 2031, with a CAGR of 11.46%[2].

Key Takeaways

• Aspirin: The aspirin market is driven by strong demand and supply chain disruptions, with a projected growth to $4.236.9 million by 2034.
• Caffeine: While not explicitly covered, caffeine's role in combination products influences its market dynamics.
• Orphenadrine Citrate: The market is growing rapidly due to the increasing prevalence of musculoskeletal disorders and the trend towards non-opioid pain management solutions, with a projected CAGR of 11.46% from 2024 to 2031.

FAQs

1. What are the primary drivers of the aspirin market?

   • The aspirin market is driven by a surge in cardiovascular diseases, combination aspirins, and strong market fundamentals along with supply chain disruptions[1][5].

2. How is the Orphenadrine Citrate market expected to grow?

   • The Orphenadrine Citrate market is anticipated to grow at a CAGR of 11.46% from 2024 to 2031, driven by the increasing incidence of chronic pain conditions and the trend towards non-opioid pain management solutions[2].

3. What regions are key players in the Orphenadrine Citrate market?

   • The Asia-Pacific region, Europe, Latin America, and the Middle East & Africa are significant regions driving the growth of the Orphenadrine Citrate market[2].

4. How does the caffeine market influence the aspirin market?

   • Caffeine, often used in combination with aspirin, influences the demand for aspirin products, particularly those designed to treat headaches and other pain conditions.

5. What is the projected market size for the aspirin drug market by 2034?

   • The global aspirin drug market is expected to reach $4,236.9 million by 2034, growing at a CAGR of 3.8% from 2024[5].

Sources

1. Procurement Resource - Aspirin Price Trend, Index, News, Chart, Database[1]
2. OpenPR - Orphenadrine Citrate Market Size, Share and Forecast By Key Players[2]
3. MarketPublishers - Covid-19 Impact on Global Orphenadrine citrate CAS 4682-36-4 Market[3]
4. The Business Research Company - Global Thyroid Cancer Drugs Market Report 2024[4]
5. PR Newswire - Aspirin Drug Market to Soar to US$4.2 Billion by 2034[5]