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Last Updated: December 22, 2024

HYDROCHLOROTHIAZIDE; PROPRANOLOL HYDROCHLORIDE - Generic Drug Details


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What are the generic drug sources for hydrochlorothiazide; propranolol hydrochloride and what is the scope of patent protection?

Hydrochlorothiazide; propranolol hydrochloride is the generic ingredient in seven branded drugs marketed by Wyeth Ayerst, Wyeth Pharms Inc, Duramed Pharms Barr, Actavis Elizabeth, Ani Pharms, Chartwell Rx, Ivax Sub Teva Pharms, Rising, Warner Chilcott, and Watson Labs, and is included in nineteen NDAs. Additional information is available in the individual branded drug profile pages.

Summary for HYDROCHLOROTHIAZIDE; PROPRANOLOL HYDROCHLORIDE
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US Patents and Regulatory Information for HYDROCHLOROTHIAZIDE; PROPRANOLOL HYDROCHLORIDE

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Chartwell Rx PROPRANOLOL HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE hydrochlorothiazide; propranolol hydrochloride TABLET;ORAL 071061-001 Aug 26, 1987 DISCN No No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
Chartwell Rx PROPRANOLOL HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE hydrochlorothiazide; propranolol hydrochloride TABLET;ORAL 071060-001 Aug 26, 1987 DISCN No No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
Wyeth Pharms Inc INDERIDE-40/25 hydrochlorothiazide; propranolol hydrochloride TABLET;ORAL 018031-001 Approved Prior to Jan 1, 1982 DISCN Yes No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
Warner Chilcott PROPRANOLOL HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE hydrochlorothiazide; propranolol hydrochloride TABLET;ORAL 071772-001 Jan 26, 1988 DISCN No No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

Expired US Patents for HYDROCHLOROTHIAZIDE; PROPRANOLOL HYDROCHLORIDE

Applicant Tradename Generic Name Dosage NDA Approval Date Patent No. Patent Expiration
Wyeth Ayerst INDERIDE LA 120/50 hydrochlorothiazide; propranolol hydrochloride CAPSULE, EXTENDED RELEASE;ORAL 019059-002 Jul 3, 1985 ⤷  Subscribe ⤷  Subscribe
Wyeth Ayerst INDERIDE LA 80/50 hydrochlorothiazide; propranolol hydrochloride CAPSULE, EXTENDED RELEASE;ORAL 019059-001 Jul 3, 1985 ⤷  Subscribe ⤷  Subscribe
Wyeth Ayerst INDERIDE LA 160/50 hydrochlorothiazide; propranolol hydrochloride CAPSULE, EXTENDED RELEASE;ORAL 019059-003 Jul 3, 1985 ⤷  Subscribe ⤷  Subscribe
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >Patent No. >Patent Expiration

HYDROCHLOROTHIAZIDE; PROPRANOLOL HYDROCHLORIDE Market Analysis and Financial Projection Experimental

Market Dynamics and Financial Trajectory for Hydrochlorothiazide and Propranolol Hydrochloride

Introduction

Hydrochlorothiazide and propranolol hydrochloride are two widely used medications in the treatment of various cardiovascular conditions. Understanding the market dynamics and financial trajectory of these drugs is crucial for pharmaceutical companies, investors, and healthcare professionals.

Hydrochlorothiazide Market Overview

Definition and Use

Hydrochlorothiazide is a diuretic used primarily to treat high blood pressure (hypertension) and edema. It works by increasing the flow of urine, which helps lower blood pressure and reduce the risk of heart attacks, strokes, and kidney failure[3].

Market Drivers

  • Increasing Prevalence of Hypertension: The global prevalence of hypertension is on the rise, with an estimated 1.13 billion people suffering from the condition. This number is expected to increase to 29% by 2025, driven largely by increases in economically developing nations[3].
  • Geriatric Population Growth: The rise in the geriatric population is a significant driver, as older adults are more likely to suffer from hypertension and other cardiovascular diseases.
  • Healthcare Expenditure: Increased healthcare expenditure and investments in research and development by pharmaceutical companies are also boosting the market growth[3].

Market Restraints

  • Side Effects: Hydrochlorothiazide is associated with several side effects, such as electrolyte imbalance, increased urination, and potential interactions with other medications, which can hamper market growth[3].

Market Trends

  • New Product Launches: The launch of novel formulations and improved versions of hydrochlorothiazide is expected to flourish the market.
  • Regional Growth: The Asia-Pacific region is anticipated to see significant growth due to the rising awareness of hypertension treatment and robust investments in healthcare infrastructure[3].

Propranolol Hydrochloride Market Overview

Definition and Use

Propranolol hydrochloride is a beta-blocker used to treat high blood pressure, chest pain (angina), and certain heart-related conditions. It works by reducing the heart rate and the force of the heart's contractions, thereby lowering blood pressure[2].

Market Drivers

  • Generic Drug Market: The increase in the design, development, and distribution of generic medicines is a major driver for the propranolol hydrochloride market. Generic drugs offer similar chemical substances and dosage routines at lower costs[1].
  • Chronic Diseases: The growing number of young adults and the geriatric population suffering from chronic diseases such as hypertension and heart conditions is driving the market growth.
  • Emerging Economies: Semi-urban and newly industrialized economies like India, China, Russia, South Africa, and Brazil (BRICS) are expected to witness significant growth in the pharmaceutical industry, including the propranolol hydrochloride market[1].

Market Restraints

  • Regulatory Requirements: Increasing regulatory requirements in Europe and Asia-Pacific regarding the development, sale, and use of generic drugs can hamper market growth.
  • High Prices and Side Effects: High prices associated with the drug and its administration, along with side effects such as congestive heart failure, thrombocytopenic purpura, and short-term memory loss, can restrain market growth in underdeveloped economies[1].

Market Trends

  • North America: This region is anticipated to witness the highest market traction due to the development of the generic drug market, the rise in the geriatric population, and increased chronic diseases combined with high disposable income to spend on healthcare facilities[1].
  • Asia-Pacific and Middle East: These regions are expected to gain market share due to rising awareness about chronic diseases and robust investments in the design and development of new generic drugs[1].

Financial Trajectory

Hydrochlorothiazide

  • The hydrochlorothiazide market is expected to grow significantly due to the increasing prevalence of hypertension and the rise in healthcare expenditure. The market is driven by the launch of new formulations and the growing awareness of heart disease treatment.
  • Market Size and Growth: The exact financial figures for the hydrochlorothiazide market are not specified, but it is anticipated to grow substantially over the forecast period, driven by the factors mentioned above[3].

Propranolol Hydrochloride

  • The propranolol hydrochloride market is projected to grow due to the increasing demand for generic drugs and the rising incidence of chronic diseases.
  • Market Size and Growth: The propranolol hydrochloride market is expected to see significant growth, particularly in North America and emerging economies. However, specific financial projections are not provided in the available sources[1].

Regional Analysis

Hydrochlorothiazide

  • Asia-Pacific: This region is expected to see significant growth due to the rising prevalence of hypertension and investments in healthcare infrastructure.
  • Europe and North America: These regions will also see growth, driven by the well-established healthcare systems and increased research and development activities[3].

Propranolol Hydrochloride

  • North America: This region is anticipated to witness the highest market traction due to the development of the generic drug market and high disposable income.
  • Asia-Pacific and Middle East: These regions are expected to gain market share due to rising awareness about chronic diseases and robust investments in the design and development of new generic drugs[1].

Competitive Landscape

Hydrochlorothiazide

  • The hydrochlorothiazide market is competitive with several key players, including pharmaceutical companies that are investing heavily in research and development.
  • Key Players: While specific key players for hydrochlorothiazide are not listed, the market is characterized by a competitive intensity with multiple pharmaceutical companies involved[3].

Propranolol Hydrochloride

  • The propranolol hydrochloride market is fragmented with several players such as Amneal Pharmaceuticals LLC, Pierre Fabre Konzern, Medtronic Ltd., Mylan Pharmaceuticals Inc., and Teva Pharmaceutical Industries Ltd.
  • Market Competition: The competition in this market is high, with companies focusing on developing new formulations and expanding their market presence[1].

Impact of COVID-19

Both the hydrochlorothiazide and propranolol hydrochloride markets have been influenced by the COVID-19 pandemic.

  • Increased Demand: The pandemic has led to a surge in demand for drugs used in the management of COVID-19 and related cardiovascular conditions, presenting opportunities for manufacturers.
  • Supply Chain Challenges: However, the pandemic has also posed significant supply chain challenges, affecting the production and distribution of these drugs[1][3].

Key Takeaways

  • Growing Demand: Both hydrochlorothiazide and propranolol hydrochloride markets are driven by the increasing prevalence of hypertension and other cardiovascular diseases.
  • Generic Drug Market: The growth of the generic drug market is a significant driver for propranolol hydrochloride.
  • Regional Growth: Asia-Pacific and emerging economies are expected to see significant growth in both markets.
  • Regulatory and Pricing Challenges: High regulatory requirements and prices can hamper market growth in certain regions.
  • COVID-19 Impact: The pandemic has both increased demand and posed supply chain challenges for these drugs.

FAQs

What are the primary uses of hydrochlorothiazide and propranolol hydrochloride?

  • Hydrochlorothiazide is primarily used to treat high blood pressure (hypertension) and edema, while propranolol hydrochloride is used to treat high blood pressure, chest pain (angina), and certain heart-related conditions[2][3].

Which regions are expected to see significant growth in these markets?

  • The Asia-Pacific region is expected to see significant growth in the hydrochlorothiazide market, while North America and emerging economies are anticipated to drive the propranolol hydrochloride market[1][3].

What are the key drivers for the growth of these markets?

  • The key drivers include the increasing prevalence of hypertension, the growth of the generic drug market, and rising healthcare expenditure[1][3].

How has COVID-19 impacted these markets?

  • COVID-19 has led to a surge in demand for these drugs due to their use in managing related cardiovascular conditions, but it has also posed significant supply chain challenges[1][3].

What are the potential restraints for these markets?

  • Side effects associated with the drugs, high prices, and increasing regulatory requirements are potential restraints for these markets[1][3].

Sources

  1. Allied Market Research: Propranolol Hydrochloride Market Size | Industry Growth By, 2030
  2. Mayo Clinic: Propranolol and hydrochlorothiazide (oral route)
  3. Allied Market Research: Hydrochlorothiazide Market Size | Industry Growth, (2021-2030)
  4. Transparency Market Research: Beta Blockers Market Size, Share, Growth, Industry Report - 2031

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