METHOHEXITAL SODIUM - Generic Drug Details

What are the generic drug sources for methohexital sodium and what is the scope of freedom to operate?

Methohexital sodium is the generic ingredient in two branded drugs marketed by Endo Operations and Steriscience Speclts, and is included in two NDAs. Additional information is available in the individual branded drug profile pages.

Three suppliers are listed for this compound.

Summary for METHOHEXITAL SODIUM

US Patents:	0
Tradenames:	2
Applicants:	2
NDAs:	2
Finished Product Suppliers / Packagers:	3
Raw Ingredient (Bulk) Api Vendors:	12
Clinical Trials:	2
Patent Applications:	1,275
What excipients (inactive ingredients) are in METHOHEXITAL SODIUM?	METHOHEXITAL SODIUM excipients list
DailyMed Link:	METHOHEXITAL SODIUM at DailyMed

Recent Clinical Trials for METHOHEXITAL SODIUM

Identify potential brand extensions & 505(b)(2) entrants

Sponsor	Phase
University of Utah	Phase 3
Rutgers, The State University of New Jersey	Phase 4

See all METHOHEXITAL SODIUM clinical trials

Pharmacology for METHOHEXITAL SODIUM

Drug Class

Barbiturate

Medical Subject Heading (MeSH) Categories for METHOHEXITAL SODIUM

Anesthetics, Intravenous

Anatomical Therapeutic Chemical (ATC) Classes for METHOHEXITAL SODIUM

N01AF	Barbiturates, plain
N01A	ANESTHETICS, GENERAL
N01	ANESTHETICS
N	Nervous system

N05CA	Barbiturates, plain
N05C	HYPNOTICS AND SEDATIVES
N05	PSYCHOLEPTICS
N	Nervous system

US Patents and Regulatory Information for METHOHEXITAL SODIUM

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
Endo Operations	BREVITAL SODIUM	methohexital sodium	INJECTABLE;INJECTION	011559-003	Approved Prior to Jan 1, 1982		DISCN	No	No
Endo Operations	BREVITAL SODIUM	methohexital sodium	INJECTABLE;INJECTION	011559-004	Dec 21, 2012		DISCN	No	No
Endo Operations	BREVITAL SODIUM	methohexital sodium	INJECTABLE;INJECTION	011559-002	Approved Prior to Jan 1, 1982		DISCN	Yes	No
Steriscience Speclts	METHOHEXITAL SODIUM	methohexital sodium	INJECTABLE;INJECTION	215488-001	Oct 3, 2024	AP	RX	No	No
Endo Operations	BREVITAL SODIUM	methohexital sodium	INJECTABLE;INJECTION	011559-001	Approved Prior to Jan 1, 1982	AP	RX	Yes	Yes

METHOHEXITAL SODIUM Market Analysis and Financial Projection Experimental

Market Dynamics and Financial Trajectory of Methohexital Sodium

Market Overview

Methohexital sodium, a rapid, ultrashort-acting barbiturate anesthetic, is used primarily for the induction of general anesthesia and deep sedation. Here’s a detailed look at the market dynamics and financial trajectory of this drug.

Global Market Size and Growth

The global methohexital sodium market has shown a steady growth trajectory. As of 2018, the market size was valued at several million dollars, with a notable Compound Annual Growth Rate (CAGR) from 2014 to 2018. It is projected to continue growing, reaching a significant market size by the end of 2024, driven by a CAGR of several percent from 2019 to 2024[1].

Regional Market Analysis

North America and Asia-Pacific

The North American and Asia-Pacific regions are significant contributors to the global methohexital sodium market. In North America, the market size and volume have been steadily increasing, with detailed data available on demand by application and type, as well as key players' sales and market share[1].

In the Asia-Pacific region, countries like China and India have shown substantial growth. The market size, volume, and demand by application and type in these regions are closely monitored, reflecting the overall market dynamics[1].

Market Drivers

Increasing Demand for Anesthetic Procedures

The demand for anesthetic procedures, particularly in surgical settings, drives the growth of the methohexital sodium market. The drug's rapid onset and short duration of action make it a preferred choice for many medical professionals[2].

Advancements in Healthcare Infrastructure

Improvements in healthcare infrastructure, especially in developing countries, have increased access to advanced medical procedures, thereby boosting the demand for methohexital sodium[4].

Market Challenges

Side Effects and Precautions

Methohexital sodium is associated with several side effects, including respiratory depression, cardiovascular issues, and neurological effects. These adverse reactions necessitate cautious use, particularly in patients with pre-existing conditions such as asthma, obstructive pulmonary disease, and severe hypertension or hypotension[2][3].

Regulatory and Policy Changes

Changes in regulatory policies and healthcare guidelines can impact the market. For instance, stricter regulations on the use of barbiturates could affect the market size and growth[4].

Competitive Landscape

The methohexital sodium market is characterized by a competitive landscape with several key vendors. These vendors compete based on production capacity, market share, and product specifications. The report provides detailed information on the company profiles, production values, and market shares of these key players[1][4].

Manufacturing Technology and Supply Chain

The manufacturing technology for methohexital sodium involves a complex process, including demethylation and oxidation in the liver for metabolism. The supply chain analysis includes an overview of raw material supply, production, and consumption statistics, as well as trade dynamics[1][4].

Financial Performance

Revenue and Market Share

The financial performance of the methohexital sodium market is reflected in its revenue and market share. Key vendors have seen varying levels of success, with market share distribution indicating a competitive but stable market environment[1].

Price Analysis

The price of methohexital sodium varies by region and type. The report provides detailed price analysis, including historical and forecasted prices, which helps in understanding the financial trajectory of the market[1][4].

Forecast and Future Trends

The market forecast for methohexital sodium indicates continued growth, driven by increasing demand for anesthetic procedures and advancements in healthcare infrastructure. However, the market will need to navigate challenges such as regulatory changes and the management of adverse effects[1][4].

Regional Forecast

Regional forecasts suggest that North America and the Asia-Pacific region will continue to be significant markets. The US market, in particular, is expected to show steady growth, with detailed forecasts available for supply, demand, and prices[4].

Raw Material Supply and Downstream Consumer Analysis

The report also includes an analysis of raw material supply and downstream consumer information. This analysis is crucial for understanding the overall market dynamics and potential future challenges or opportunities[4].

Key Takeaways

• Global Growth: The global methohexital sodium market is expected to grow, driven by increasing demand for anesthetic procedures.
• Regional Importance: North America and the Asia-Pacific region are key markets.
• Competitive Landscape: The market is competitive with several key vendors.
• Regulatory Challenges: The market faces challenges from regulatory changes and adverse effects.
• Financial Performance: The market shows stable financial performance with varying levels of success among key vendors.

FAQs

1. What is methohexital sodium used for?

Methohexital sodium is used as an intravenous anesthetic for the induction of general anesthesia and deep sedation[2][5].

2. What are the common side effects of methohexital sodium?

Common side effects include respiratory depression, cardiovascular issues, neurological effects, and gastrointestinal symptoms such as nausea and vomiting[2][3].

3. How does the metabolism of methohexital sodium occur?

Metabolism occurs in the liver through demethylation and oxidation, with side-chain oxidation being the most important biotransformation involved in terminating its biologic activity[2][5].

4. What regions are significant in the global methohexital sodium market?

North America and the Asia-Pacific region, particularly countries like China and India, are significant contributors to the global market[1][4].

5. What are the market drivers for methohexital sodium?

The market is driven by increasing demand for anesthetic procedures and advancements in healthcare infrastructure[4].

Cited Sources

1. Global Methohexital Sodium Market Report 2019 - Market Publishers
2. Methohexital Sodium: Package Insert / Prescribing Info - Drugs.com
3. Methohexital Monograph for Professionals - Drugs.com
4. 2018 US Methohexital Sodium Industry Report - Market Publishers
5. Methohexital: Uses, Interactions, Mechanism of Action - DrugBank