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Last Updated: December 22, 2024

VERATRUM VIRIDE ROOT - Generic Drug Details


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What are the generic drug sources for veratrum viride root and what is the scope of freedom to operate?

Veratrum viride root is the generic ingredient in one branded drug marketed by Medpointe Pharm Hlc and is included in one NDA. Additional information is available in the individual branded drug profile pages.

Summary for VERATRUM VIRIDE ROOT
US Patents:0
Tradenames:1
Applicants:1
NDAs:1
DailyMed Link:VERATRUM VIRIDE ROOT at DailyMed
Anatomical Therapeutic Chemical (ATC) Classes for VERATRUM VIRIDE ROOT

US Patents and Regulatory Information for VERATRUM VIRIDE ROOT

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Medpointe Pharm Hlc VERTAVIS veratrum viride root TABLET;ORAL 005691-002 Approved Prior to Jan 1, 1982 DISCN No No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

VERATRUM VIRIDE ROOT Market Analysis and Financial Projection Experimental

Market Dynamics and Financial Trajectory for Veratrum Viride Root

Introduction

Veratrum viride, commonly known as the green or American hellebore, is a highly toxic plant with a rich history in traditional medicine. The root of this plant, particularly, has been utilized for its medicinal properties, especially in the treatment of cardiovascular conditions. Here, we will delve into the market dynamics and financial trajectory of the Veratrum viride root.

Historical Use and Medical Significance

Historically, Veratrum viride has been employed in medicine, particularly for its cardiac depressant properties. In the early 1850s, it gained popularity after a South Carolina doctor demonstrated its effectiveness in treating pneumonia and other conditions[4]. The root and rhizome of Veratrum viride contain a mixture of alkaloids, with protoveratrin being the primary active component. These alkaloids are responsible for the plant's therapeutic effects, including slowing the pulse and lowering blood pressure, which made it a valuable treatment for conditions like eclampsia[5].

Market Demand and Supply

Traditional Medicine

The demand for Veratrum viride root has historically been driven by its use in traditional medicine. However, with the advent of modern pharmaceuticals, its use has significantly declined. In the past, it was a sought-after ingredient for treating high blood pressure and rapid heartbeat, but its toxicity and the availability of safer alternatives have reduced its market demand[1][5].

Modern Herbalism

Despite its reduced use in mainstream medicine, Veratrum viride still finds niche applications in modern herbalism. Some Native American nations continue to use it externally for various ailments, although its internal use is rare due to its high toxicity[1].

Commercial Cultivation

Unlike some other medicinal plants, Veratrum viride is not widely cultivated commercially. Its cultivation is challenging due to its specific habitat requirements and the risks associated with its toxicity. This lack of commercial cultivation contributes to its limited availability and higher costs when it is sourced from wild populations[2].

Pricing and Financial Aspects

Historical Pricing

In the past, when Veratrum viride was more widely used, its pricing was influenced by supply and demand dynamics. For example, in the 1970s, various wild roots and herbs, including those with medicinal properties, were priced based on their demand and availability. However, specific pricing data for Veratrum viride from that era is not readily available[3].

Current Market

Today, the market for Veratrum viride root is relatively small and specialized. The plant is not commonly traded, and its price can vary significantly depending on the source, quality, and quantity. Given its toxicity and limited use, it is not a lucrative market, and the financial returns are generally modest.

Regulatory and Safety Considerations

Toxicity and Safety

The high toxicity of Veratrum viride is a significant factor affecting its market dynamics. The plant contains over 200 different alkaloids, which can cause severe symptoms including nausea, vomiting, and even bradycardia if ingested in large quantities. This toxicity necessitates strict regulatory oversight and caution in handling and use[2].

Regulatory Environment

Regulations around the use and trade of Veratrum viride vary by region. In many places, it is classified as a poisonous plant, and its sale and use are heavily regulated. These regulations can impact the supply chain and pricing, making it more difficult and expensive to obtain the root for medicinal purposes.

Competition and Alternatives

Pharmaceutical Alternatives

The development of modern pharmaceuticals has significantly reduced the demand for Veratrum viride. Safer and more effective medications for treating cardiovascular conditions have become the preferred choice, further diminishing the market for this plant[5].

Other Herbal Remedies

Other herbal remedies with similar therapeutic effects but lower toxicity have also competed with Veratrum viride. Plants like digitalis (from Digitalis purpurea) and others have become more popular due to their safer profiles and proven efficacy.

Future Outlook

Declining Demand

Given the availability of safer and more effective treatments, the demand for Veratrum viride root is likely to continue declining. Its use is now largely limited to niche applications in traditional medicine and some specialized herbal practices.

Conservation Concerns

The wild harvesting of Veratrum viride, along with other medicinal plants, raises conservation concerns. Efforts to protect wild plant populations and promote sustainable harvesting practices may further impact the availability and pricing of the root.

Key Takeaways

  • Historical Significance: Veratrum viride has a rich history in traditional medicine, particularly for its cardiac depressant properties.
  • Limited Market: The current market for Veratrum viride root is small and specialized, with limited demand due to its toxicity and the availability of safer alternatives.
  • Regulatory Oversight: Strict regulations due to its high toxicity affect the supply chain and pricing.
  • Competition from Pharmaceuticals: Modern pharmaceuticals have significantly reduced the demand for Veratrum viride.
  • Conservation Concerns: Wild harvesting raises conservation issues, which may impact future availability.

FAQs

What are the primary medicinal uses of Veratrum viride root?

The primary medicinal uses of Veratrum viride root include treating high blood pressure, rapid heartbeat, and conditions like eclampsia due to its cardiac depressant properties.

Why is the demand for Veratrum viride root declining?

The demand is declining due to the availability of safer and more effective modern pharmaceuticals, as well as the plant's high toxicity.

Is Veratrum viride commercially cultivated?

Veratrum viride is not widely commercially cultivated due to its specific habitat requirements and the risks associated with its toxicity.

What are the regulatory considerations for Veratrum viride?

The plant is heavily regulated due to its high toxicity, and its sale and use are subject to strict oversight in many regions.

What are the conservation concerns related to Veratrum viride?

Wild harvesting of Veratrum viride raises conservation concerns, and efforts to protect wild plant populations may impact its availability and pricing.

Sources

  1. Wikipedia: Veratrum viride
  2. Science.gov: Veratrum album ssp
  3. RNGR: A Survey of Some Marketable Wild Plants
  4. JSTOR: Nature's Emporium: The Botanical Drug Trade
  5. JAMA Internal Medicine: The Clinical Actions of Veratrum

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