Drugs in MeSH Category Acid Sensing Ion Channel Blockers

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
Chartwell Rx	AMILORIDE HYDROCHLORIDE	amiloride hydrochloride	TABLET;ORAL	204180-001	Aug 7, 2015		DISCN	No	No
Endo Operations	AMILORIDE HYDROCHLORIDE	amiloride hydrochloride	TABLET;ORAL	070346-001	Jan 22, 1986	AB	RX	No	Yes
Padagis Us	MIDAMOR	amiloride hydrochloride	TABLET;ORAL	018200-001	Approved Prior to Jan 1, 1982	AB	RX	Yes	No
Sigmapharm Labs Llc	AMILORIDE HYDROCHLORIDE	amiloride hydrochloride	TABLET;ORAL	079133-001	Jan 30, 2009	AB	RX	No	No

Acid Sensing Ion Channel Blockers Market Analysis and Financial Projection

The market dynamics and patent landscape for Acid-Sensing Ion Channel (ASIC) blockers reflect a growing focus on neurological and pain-related therapeutic applications, driven by both academic research and pharmaceutical innovation. Here's a synthesis of key trends and developments:

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Market Dynamics

1. Therapeutic Potential
   ASIC blockers are being explored for neuroprotection, pain management (including migraines and inflammatory pain), and conditions like epilepsy and ischemic stroke[1][5][14][19]. Their role in modulating intracellular pH and Ca²⁺ influx makes them critical in acidosis-related pathologies, such as stroke and neurodegenerative diseases[3][10].

2. Growth Drivers

   • Unmet Medical Needs: Chronic pain and neurological disorders lack universally effective treatments, creating demand for novel targets like ASICs[1][16].
   • Drug Repurposing: Existing drugs like amiloride (a weak ASIC inhibitor) are being repurposed due to their safety profiles, accelerating development timelines[14][19].
   • Neuroprotection: ASIC1a blockers (e.g., C5b) show promise in reducing neuronal damage during ischemia, with improved blood-brain barrier (BBB) penetration compared to earlier inhibitors[3].

3. Challenges

   • Selectivity: Many ASIC blockers (e.g., amiloride) lack specificity, affecting other ion channels and causing side effects[5][19].
   • Delivery: Poor BBB permeability of peptide-based inhibitors (e.g., PcTx1) limits their clinical utility[3][14].
   • Complex Mechanisms: Dual roles of ASICs in pain and neuroprotection require balanced pharmacological tuning[2][10].

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Patent Landscape

1. Key Innovations

   • Toxin-Derived Compounds: Psalmotoxin-1 (PcTx1) from tarantula venom is patented for ASIC1a inhibition, offering nanomolar potency[1][19].
   • Small Molecules: Pyrazinoylguanidine derivatives (e.g., Parion Sciences’ patents) target ASIC-mediated pain and cough suppression[12].
   • BBB-Permeable Agents: Novel compounds like C5b, inspired by natural toxins, are designed for CNS applications with enhanced delivery[3].

2. Strategic Patenting

   • Method Patents: Claims cover treatment methods for ASIC-related disorders, including neuropathic pain and ischemic injury[8][12].
   • Structural Diversification: Patents emphasize scaffold modifications to improve selectivity (e.g., Merck’s T-type Ca²⁺ inhibitors)[6].
   • Combination Therapies: Some filings combine ASIC blockers with existing analgesics or anti-inflammatory agents[12].

3. Competitive Players

   • Academic Institutions: The University of Rochester holds foundational patents on ion channel modulation, though focused on cox-2 inhibitors[4].
   • Biotech Firms: Parion Sciences leads in sodium/ASIC channel blockers, with patents on pyrazinoylguanidines for pain and cough[12].
   • Pharmaceutical Giants: Companies like Merck and Pfizer invest in ion channel modulators, though ASIC-specific pipelines remain niche[6][16].

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Emerging Trends

1. Collaborative Research: Public-private partnerships (e.g., MLPCN) aim to develop ASIC blockers free from intellectual property constraints[6].
2. Targeted Delivery: Nanotechnology and prodrug strategies are being patented to enhance BBB penetration[3][14].
3. Biomarker Integration: Patents increasingly incorporate diagnostic biomarkers to personalize ASIC blocker therapies[16].

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Future Outlook

The ASIC blocker market is poised for growth, driven by advances in structural biology (e.g., cryo-EM mapping of ASIC channels)[5] and high-throughput screening. However, success hinges on overcoming selectivity hurdles and validating clinical efficacy in neurology-driven trials. With ion channels representing ~19% of marketed drugs[16], ASIC-focused innovations could capture a significant share of the $35B+ ion channel drug market by 2032[9][15].

References

1. https://pmc.ncbi.nlm.nih.gov/articles/PMC2267925/
2. https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2023.1131661/full
3. https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.849498/full
4. https://www.rochester.edu/pr/Review/V63N1/year20.html
5. https://en.wikipedia.org/wiki/Acid-sensing_ion_channel
6. https://pmc.ncbi.nlm.nih.gov/articles/PMC3285241/
7. https://rupress.org/jgp/article/154/7/e202213156/213225/Structural-determinants-of-acid-sensing-ion
8. https://patents.google.com/patent/US10933055B1/en
9. https://www.einpresswire.com/article/779270317/asic-chip-market-is-booming-worldwide-2025-2032-broadcom-inc-comport-data
10. https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2023.1194948/full
11. https://www.fbrice.com.au/ip-news-insights/traversing-a-dynamic-adc-patent-landscape-2/
12. https://patents.justia.com/assignee/parion-sciences-inc?page=7
13. https://www.imec-int.com/en/articles/asics-allow-cost-effective-ip-protection-for-technology-inventions
14. https://pubmed.ncbi.nlm.nih.gov/30539804/
15. https://www.einpresswire.com/article/795232682/asic-chip-market-set-to-witness-significant-growth-by-2025-2032-comport-data-dwin-technology
16. https://www.grandviewresearch.com/market-trends/ion-channels-in-drug-discovery
17. https://anr.fr/Project-ANR-13-BSV4-0009
18. https://www.pharmexec.com/view/the-shifting-pharmacy-landscape-in-2025
19. https://pubmed.ncbi.nlm.nih.gov/26563811/