Claims for Patent: 10,034,867

Summary for Patent: 10,034,867

Title:	Quinuclidine derivatives and medicinal compositions containing the same
Abstract:	Provided is a powder inhaler comprising a powder inhalant comprising 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicy- clo[2.2.2]octane wherein an anion X.sup.- is associated with the positive charge of the nitrogen atom and wherein X.sup.- is a pharmaceutically acceptable anion of a mono- or polyvalent acid.
Inventor(s):	Fernandez Forner; Maria Dolors (Barcelona, ES), Prat Quinones; Maria (Barcelona, ES), Buil Albero; Maria Antonia (Barcelona, ES)
Assignee:	ALMIRALL, S.A. (Barcelona, ES)
Application Number:	15/599,646
Patent Claims:	1. A powder inhaler comprising a powder inhalant comprising 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicy- clo[2.2.2]octane wherein an anion X.sup.- is associated with the positive charge of the nitrogen atom and wherein X.sup.- is a pharmaceutically acceptable anion of a mono- or polyvalent acid. 2. The powder inhaler of claim 1, wherein X.sup.- is bromide ion. 3. The powder inhaler of claim 1, wherein the powder inhalant further comprises a pharmaceutically acceptable carrier or diluent. 4. The powder inhaler of claim 3, wherein the pharmaceutically acceptable carrier or diluent of the powder inhalant is lactose. 5. The powder inhaler of claim 1, wherein the powder inhalant further comprises a .beta..sub.2 agonist. 6. The powder inhaler of claim 5, wherein the powder inhalant further comprises a steroid or a phosphodiesterase IV inhibitor. 7. The powder inhaler of claim 1, wherein the powder inhalant further comprises a steroid. 8. The powder inhaler of claim 7, wherein the powder inhalant further comprises a phosphodiesterase IV inhibitor. 9. The powder inhaler of claim 1, wherein the powder inhalant further comprises a phosphodiesterase IV inhibitor. 10. A method for treating chronic obstructive pulmonary disease, chronic bronchitis, bronchial hyperreactivity, asthma, or rhinitis which method comprises use of a powder inhaler of claim 1 to administer to a human patient in need of such treatment an effective amount of the powder inhalant of claim 1. 11. The method of claim 10 further comprising administering an effective amount of a .beta..sub.2 agonist. 12. The method of claim 11 further comprising administering an effective amount of a steroid or a phosphodiesterase IV inhibitor. 13. The method of claim 10 further comprising administering an effective amount of a steroid. 14. The method of claim 13 further comprising administering an effective amount of a phosphodiesterase IV inhibitor. 15. The method of claim 10 further comprising administering an effective amount of a phosphodiesterase IV inhibitor. 16. A method for inhibiting bronchospasm, which method comprises use of a powder inhaler of claim 1 to administer to a human patient in need of such treatment an effective amount of the powder inhalant of claim 1. 17. The method of claim 16 further comprising administering an effective amount of a .beta..sub.2 agonist. 18. The method of claim 17 further comprising administering an effective amount of a steroid or a phosphodiesterase IV inhibitor. 19. The method of claim 16 further comprising administering an effective amount of a steroid. 20. The method of claim 19 further comprising administering an effective amount of a phosphodiesterase IV inhibitor. 21. The method of claim 16 further comprising administering an effective amount of a phosphodiesterase IV inhibitor.