Claims for Patent: 10,130,591
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Summary for Patent: 10,130,591
| Title: | Abuse-proofed dosage form |
| Abstract: | The present invention relates to an abuse-proofed, thermoformed dosage form containing, in addition to one or more active ingredients with abuse potential optionally together with physiologically acceptable auxiliary substances, at least one synthetic or natural polymer with a breaking strength of at least 500 N and to a process for the production thereof. |
| Inventor(s): | Bartholomaus; Johannes (Aachen, DE), Kugelmann; Heinrich (Aachen, DE), Arkenau-Mari ; Elisabeth (Koln, DE) |
| Assignee: | GRUNENTHAL GMBH (Aachen, DE) |
| Application Number: | 15/265,263 |
| Patent Claims: |
1. An abuse-proofed, thermoformed dosage form having a breaking strength of at least 500 N, said dosage form being in the form of a tablet obtained by a process
comprising: a) mixing: i) an opioid or a physiologically acceptable salt thereof; ii) optionally physiologically acceptable substances (B); iii) at least one polyalkylene oxide (C) having a molecular weight of 1-15 million according to rheological
measurements, wherein the content of component (C) is at least 60 wt. %, relative to the total weight of the tablet; and iv) optionally at least one wax (D); to form a resultant mixture; b) press-forming the resultant mixture to form a press-formed
product; and c) exposing the press-formed product to heat to yield the dosage form.
2. A dosage form according to claim 1, wherein the opioid or physiologically acceptable salt thereof is oxycodone or a physiologically acceptable salt thereof. 3. A method of treating pain in a patient suffering therefrom, said method comprising administering to said patient a dosage form according to claim 1. 4. A dosage form according to claim 1, wherein the opioid or physiologically acceptable salt thereof is morphine or a physiologically acceptable salt thereof. 5. A method according to claim 3, wherein the opioid or physiologically acceptable salt thereof is oxycodone or a physiologically acceptable salt thereof. 6. A method according to claim 3, wherein the opioid or physiologically acceptable salt thereof is morphine or a physiologically acceptable salt thereof. |
