Claims for Patent: 10,206,887

Summary for Patent: 10,206,887

Title:	Prion free nanoparticle compositions and methods of making thereof
Abstract:	The present invention provides prion-free compositions comprising nanoparticles comprising albumin and substantially water insoluble drugs. Also provided are methods of making prion-free compositions and methods of removing prion proteins from the nanoparticle compositions. Methods of using the compositions, as well as kits useful for carrying out the methods are also provided.
Inventor(s):	Desai; Neil P. (Los Angeles, CA), Peykov; Viktor (San Diego, CA), Soon-Shiong; Patrick (Los Angeles, CA)
Assignee:	Abraxis BioScience, LLC (Summit, NJ)
Application Number:	15/239,680
Patent Claims:	1. A composition comprising nanoparticles comprising a taxane coated with albumin and a ligand capable of binding a prion protein, wherein the nanoparticles in the composition have a negative zeta potential. 2. The composition of claim 1, wherein the taxane is paclitaxel. 3. The composition of claim 1, wherein the ligand is a peptide. 4. The composition of claim 1, wherein the ligand is a triazine-based compound. 5. The composition of claim 1, wherein the ligand is an antibody that recognizes a prion protein. 6. The composition of claim 5, wherein the antibody is 3F4, 6H4, 16A18, ICSM-4, or ICSM-10. 7. The composition of claim 1, wherein the ligand is a polymeric material that binds to prion proteins. 8. The composition of claim 7, wherein the polymeric material comprises an amino group, a phenyl group, or a methacrylate backbone. 9. The composition of claim 1, further comprising a supporting material. 10. The composition of claim 9, wherein the supporting material is selected from the group consisting of a resin, a bead, and a membrane. 11. The composition of claim 1, wherein the nanoparticles in the composition have an average diameter of no greater than about 200 nm. 12. A composition comprising nanoparticles comprising rapamycin coated with albumin and a ligand capable of binding a prion protein, wherein the nanoparticles in the composition have a negative zeta potential. 13. The composition of claim 12, wherein the ligand is a peptide. 14. The composition of claim 12, wherein the ligand is a triazine-based compound. 15. The composition of claim 12, wherein the ligand is an antibody that recognizes a prion protein. 16. The composition of claim 15, wherein the antibody is 3F4, 6H4, 16A18, ICSM-4, or ICSM-10. 17. The composition of claim 12, wherein the ligand is a polymeric material that binds to prion proteins. 18. The composition of claim 17, wherein the polymeric material comprises an amino group, a phenyl group, or a methacrylate backbone. 19. The composition of claim 12, further comprising a supporting material. 20. The composition of claim 19, wherein the supporting material is selected from the group consisting of a resin, a bead, and a membrane. 21. The composition of claim 12, wherein the nanoparticles in the composition have an average diameter of no greater than about 200 nm.