You're using a free limited version of DrugPatentWatch: Upgrade for Complete Access

Last Updated: November 22, 2024

Claims for Patent: 10,406,143

✉ Email this page to a colleague

« Back to Dashboard

Summary for Patent: 10,406,143

Title:	Methods for treatment of fabry disease
Abstract:	Provided are in vitro and in vivo methods for determining whether a patient with Fabry disease will respond to treatment with a specific pharmacological chaperone.
Inventor(s):	Lockhart; David J. (Emerald Hills, CA), Castelli; Jeff (New Hope, PA)
Assignee:	Amicus Therapeutics, Inc. (Cranbury, NJ)
Application Number:	15/974,222
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 10,406,143
Patent Claims:	1. A method for treatment of Fabry disease in a human patient in need thereof, the method comprising administering to the patient a therapeutically effective dose of 1-deoxygalactonojirimycin or a salt thereof, wherein the patient has an .alpha.-galactosidase A mutation selected from the group consisting of D244N, E59K, F113L, G144V, G183D, G328A, I91T, L32P, M284T, M296V, N263S, R363C, R363H, N34S, T41I, M51K, A97V, R112H, A143T, P205T, Y207S, N215S, P259R, N263S, L300P, E358A, P409A, S201F and F295C, and wherein the patient is administered about 150 mg of the 1-deoxygalactonojirimycin or salt thereof every other day. 2. The method of claim 1, wherein the 1-deoxygalactonojirimycin or salt thereof enhances .alpha.-galactosidase A activity. 3. The method of claim 1, wherein the patient is male. 4. The method of claim 1, wherein the patient is female. 5. The method of claim 1, wherein the mutation is D244N. 6. The method of claim 1, wherein the mutation is E59K. 7. The method of claim 1, wherein the mutation is F113L. 8. The method of claim 1, wherein the mutation is G144V. 9. The method of claim 1, wherein the mutation is G183D. 10. The method of claim 1, wherein the mutation is G328A. 11. The method of claim 1, wherein the mutation is I91T. 12. The method of claim 1, wherein the mutation is L32P. 13. The method of claim 1, wherein the mutation is M284T. 14. The method of claim 1, wherein the mutation is M296V. 15. The method of claim 1, wherein the mutation is N263S. 16. The method of claim 1, wherein the mutation is R363C. 17. The method of claim 1, wherein the mutation is R363H. 18. The method of claim 1, wherein the mutation is N34S. 19. The method of claim 1, wherein the mutation is T41I. 20. The method of claim 1, wherein the mutation is M51K. 21. The method of claim 1, wherein the mutation is A97V. 22. The method of claim 1, wherein the mutation is R112H. 23. The method of claim 1, wherein the mutation is A143T. 24. The method of claim 1, wherein the mutation is P205T. 25. The method of claim 1, wherein the mutation is Y207S. 26. The method of claim 1, wherein the mutation is N215S. 27. The method of claim 1, wherein the mutation is P259R. 28. The method of claim 1, wherein the mutation is N263S. 29. The method of claim 1, wherein the mutation is L300P. 30. The method of claim 1, wherein the mutation is E358A. 31. The method of claim 1, wherein the mutation is P409A. 32. The method of claim 1, wherein the mutation is S201F. 33. The method of claim 1, wherein the mutation is F295C.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.