Claims for Patent: 10,493,103

Summary for Patent: 10,493,103

Title:	Peroxide formulations and methods and applicators for using the same
Abstract:	Embodiments are directed to a stable composition comprising stabilized hydrogen peroxide and 2-propanol and applicators configured to store, dispense, and apply such stable compositions. Such compositions may be used to treat skin conditions such as warts, condyloma accuminatum, molluscum contagiosum, acrochordons, seborrheic keratosis, or a combination thereof. Some embodiments also describe take home compositions, in office compositions, over-the-counter compositions, and kits for the use of such compositions.
Inventor(s):	Shanler; Stuart D. (Malvern, PA), Powala; Christopher (Radnor, PA), Phillips; Christopher (Doylestown, PA), Beger; Brian (Newtown, PA), Greenaway Evans; Charles Rodney (Surrey, GB), Lim; Sian Tiong (Surrey, GB), Brown; Marc Barry (Watford, GB), Botta; Michael A. (Ridge, NY), Nagler; Thomas (Greenlawn, NY)
Assignee:	Aclaris Therapeutics, Inc. (Wayne, PA)
Application Number:	16/159,894
Patent Claims:	1. An applicator configured to store and dispense a topical composition comprising from about 25% w/w to about 50% w/w hydrogen peroxide and about 1% w/w to about 10% w/w 2-propanol, the applicator comprising: a frangible ampoule having the composition disposed therein, wherein the frangible ampoule is formed from borosilicate glass; an applicator body having the frangible ampoule arranged therein; an applicator hub fixedly attached to the applicator body; a tip fixedly arranged within a central bore at a proximal end of the applicator hub; and a filter arranged between the frangible ampoule and the applicator hub. 2. The applicator of claim 1 wherein the applicator body further comprises an additional ingredient of the topical composition disposed therein, whereby the agent is released from the frangible ampoule responsive to the frangible ampoule being ruptured and is mixed with the additional ingredient in the applicator body prior to administration of the topical composition. 3. The applicator of claim 1, wherein the frangible ampoule has the topical composition disposed therein, and said topical composition is released from the frangible ampoule responsive to the frangible ampoule being ruptured and flows through the applicator body, the filter, and out of the applicator through the tip. 4. The applicator of claim 1, further comprising a pressure area arranged on an outer surface of the applicator body to indicate a portion of the applicator body to apply pressure to rupture the frangible ampoule. 5. The applicator of claim 1, wherein the applicator body is formed from polypropylene, high-density polyethylene, low-density polyethylene, polyvinyl chloride, polyethylene, or a combination thereof. 6. The applicator of claim 1, wherein the filter is configured to prevent shards of a ruptured frangible ampoule from passing through and to allow the topical composition to flow through. 7. The applicator of claim 1, wherein the filter is formed from at least one of polypropylene, high-density polyethylene, low-density polyethylene, polyethylene, polystyrene, a ceramic material, a foam material, sand, diatomaceous earth, and paper fibers. 8. The applicator of claim 1, wherein the frangible ampoule has the topical composition disposed therein, wherein said topical composition comprises about 25% to about 50% w/w hydrogen peroxide and about 1% to about 5% w/w 2-propanol. 9. The applicator of claim 1, wherein the applicator hub forms a hermetic seal with the applicator body. 10. The applicator of claim 1, wherein the applicator further comprises a debriding element arranged on an exterior portion of the applicator. 11. An applicator configured to store and dispense a topical composition comprising from about 25% w/w to about 50% w/w hydrogen peroxide and about 1% w/w to about 10% w/w 2-propanol, the applicator comprising: a frangible ampoule having the topical composition disposed therein, an applicator body having the frangible ampoule arranged therein; an applicator hub fixedly attached to the applicator body; a tip fixedly arranged within a central bore at a proximal end of the applicator hub; and a filter arranged between the frangible ampoule and the applicator hub. 12. The applicator of claim 11, wherein the frangible ampoule is formed from at least on of glass, plastic, borosilicate glass, Type 1 borosilicate glass, and tinted glass. 13. The applicator of claim 11, wherein the applicator body is formed from polypropylene, high-density polyethylene, low-density polyethylene, polyvinyl chloride, polyethylene, or a combination thereof. 14. The applicator of claim 11, wherein the filter is configured to prevent shards of a ruptured frangible ampoule from passing through and to allow the topical composition to flow through. 15. The applicator of claim 11, wherein the filter is formed from at least one of polypropylene, high-density polyethylene, low-density polyethylene, polyethylene, polystyrene, a ceramic material, a foam material, sand, diatomaceous earth, and paper fibers. 16. The applicator of claim 11, wherein the topical composition comprises about 40% w/w hydrogen peroxide to about 50% w/w hydrogen peroxide. 17. The applicator of claim 11, wherein the topical composition comprises about 5% w/w 2-propanol. 18. The applicator of claim 11 wherein the applicator body further comprises an additional ingredient of the topical composition disposed therein, whereby the topical composition is released from the frangible ampoule responsive to the frangible ampoule being ruptured and is mixed with the additional ingredient in the applicator body prior to administration of the topical composition. 19. The applicator of claim 11, wherein the topical composition is released from the frangible ampoule responsive to the frangible ampoule being ruptured and flows through the applicator body, the filter, and out of the applicator through the tip. 20. The applicator of claim 11, further comprising a pressure area arranged on an outer surface of the applicator body to indicate a portion of the applicator body to apply pressure to rupture the frangible ampoule. 21. The applicator of claim 11, wherein the applicator hub forms a hermetic seal with the applicator body.