Claims for Patent: 10,517,882

Summary for Patent: 10,517,882

Title:	Method for healing of an infected acne lesion without scarring
Abstract:	Methods of treatment and dosage regimes using hydrophobic gel or foam compositions comprising a tetracycline antibiotic for accelorating the return of skin integrity and or in treating or alleviating a disorder including impetigo, acne, rosacea, a skin disease caused by a bacteria or a tetracycline antibiotic responsive disease, wherein the foam composition or gel is administered topically to a target area on a subject having the disorder and wherein the target area comprises an area of skin, or mucosa or an eye.
Inventor(s):	Tamarkin; Dov (Maccabim, IL), Gazal; Elana (Rehovot, IL), Keynan; Rita (Rehovot, IL), Eini; Meir (Ness Ziona, IL), Schuz; David (Gimzu, IL)
Assignee:	Foamix Pharmaceuticals Ltd. (Rehovot, IL)
Application Number:	15/816,850
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 10,517,882
Patent Claims:	1. A method for healing of an infected acne lesion without scarring, comprising topically administering at least once daily an effective amount of a minocycline antibiotic foam to an infected acne lesion, wherein the minocycline antibiotic foam is produced from a foamable composition upon addition of a liquefied or compressed gas propellant, the foamable composition comprising: (a) 60% to 90% by weight of one or more hydrophobic oils selected from the group consisting of a mineral oil, a soybean oil, a coconut oil, cyclomethicone, and a mixture of two or more thereof; (b) a wax selected from the group consisting of a beeswax, a hydrogenated castor oil, and a mixture thereof; (c) at least one solid fatty alcohol having a carbon chain length of 14 to 22 carbons; (d) at least one solid fatty acid having a carbon chain length of 12 to 28 carbons; and (e) 0.2% to 10% by weight of a minocycline; and wherein the foamable composition does not comprise a surfactant. 2. The method of claim 1, wherein the minocycline is present in a free base form, a salt form, a hydrate form, or a complex form. 3. The method of claim 1, wherein the minocycline is 1 to 4% by weight of the foamable composition. 4. The method of claim 1, wherein the at least one solid fatty alcohol is selected from the group consisting of myristyl alcohol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, and a mixture of two or more thereof. 5. The method of claim 1, wherein the least one solid fatty acid having a carbon chain length of 12 to 28 carbons comprises stearic acid. 6. The method of claim 1, wherein the foamable composition further comprises fumed silica. 7. The method of claim 1, wherein the minocycline is micronized. 8. The method of claim 1, wherein the foamable composition further comprises an additional active agent.