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Last Updated: July 27, 2024

Claims for Patent: 10,548,909

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Summary for Patent: 10,548,909

Title:	Co-crystals of tramadol and coxibs
Abstract:	The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
Inventor(s):	Plata Salaman; Carlos Ramon (Barcelona, ES), Tesson; Nicolas (L'Hospitalet de Llobregat, ES)
Assignee:	ESTEVE PHARMACEUTICALS, S.A. (Barcelona, ES)
Application Number:	16/275,437
Patent Claims:	1. A method of treatment of severe to moderate pain comprising administering to a patient in need thereof an effective amount of a co-crystal comprising (rac)-tramadol.HCl and celecoxib in a molecular ratio of 1:1, characterized in that it shows a Powder X-Ray Diffraction pattern with peaks [2.theta.] at 14.1, 16.8, 19.0 and 22.7[.degree.], with the 2.theta. values being obtained using copper radiation (CuK.alpha.1 1.54060 .ANG.). 2. The method of treatment of severe to moderate pain of claim 1, characterized in that the co-crystal shows additional peaks [2.theta.] at 7.1, 19.9 and 20.5[.degree.]. 3. The method of treatment of severe to moderate pain of claim 2, characterized in that the co-crystal shows additional peaks [2.theta.] at 13.6, 13.9, 17.5, 18.0, 19.5, 21.2, 21.3, 21.8, 22.6, 23.6, 24.1, 24.4 and 26.1[.degree.]. 4. A method of treatment of mild pain comprising administering to a patient in need thereof an effective amount of a co-crystal comprising (rac)-tramadol.HCl and celecoxib in a molecular ratio of 1:1, characterized in that it shows a Powder X-Ray Diffraction pattern with peaks [2.theta.] at 14.1, 16.8, 19.0 and 22.7[.degree.], with the 2.theta. values being obtained using copper radiation (CuK.alpha.1 1.54060 .ANG.). 5. The method of treatment of mild pain of claim 4, characterized in that the co-crystal shows additional peaks [2.theta.] at 7.1, 19.9 and 20.5[.degree.]. 6. The method of treatment of mild pain of claim 5, characterized in that the co-crystal shows additional peaks [2.theta.] at 13.6, 13.9, 17.5, 18.0, 19.5, 21.2, 21.3, 21.8, 22.6, 23.6, 24.1, 24.4 and 26.1[.degree.].

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