Claims for Patent: 10,576,165

Summary for Patent: 10,576,165

Title:	ST-246 liquid formulations and methods
Abstract:	The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the formulation.
Inventor(s):	Tyavanagimatt; Shanthakumar R. (Corvallis, OR), Anderson; Melialani A. C. L. S. (Corvallis, OR), Weimers; William (Corvallis, OR), Kasi; Gopi Krishna (Lynnwood, WA), Samuel; N K Peter (Corvallis, OR), Bolken; Tove C. (Keizer, OR), Hruby; Dennis E. (Albany, OR)
Assignee:	Siga Technologies Inc. (Corvallis, OR)
Application Number:	16/157,343
Patent Claims:	1. A unit dosage liquid formulation comprising: a) ST-246 content ranging from about 2 mg/ml to about 20 mg/ml; and b) hydroxypropyl-.beta.-cyclodextrin content ranging from about 125 mg/ml to about 400 mg/ml. 2. The unit dosage liquid formulation of claim 1 further comprising one or more pharmaceutically acceptable ingredients selected from the group consisting of: mannitol, trehalose dehydrate, lactose monohydrate, and purified water. 3. The unit dosage liquid formulation of claim 1 having a pH range from about 3.0 to about 10.0. 4. The unit dosage liquid formulation of claim 1 having a total volume of about 100 ml. 5. A unit dosage liquid formulation comprising: a) ST-246 ranging from about 2 mg/ml to about 20 mg/ml; and hydroxypropyl-.beta.-cyclodextrin content ranging from about 12.5 mg/ml to about 40 mg/ml. 6. The unit dosage liquid formulation of claim 5 further comprising one or more pharmaceutically acceptable ingredients selected from the group consisting of: polyethylene glycol 400, polysorbate 80, polyethylene glycol 300, and purified water. 7. The unit dosage liquid formulation of claim 5 having a total volume of about 100 ml. 8. The unit dosage liquid formulation of claim 5 having a pH range from about 3.0 to about 10.0.