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Last Updated: March 17, 2025

Claims for Patent: 10,654,855

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Summary for Patent: 10,654,855

Title:	Protein kinase B inhibitors
Abstract:	The invention relates to a novel group of compounds of Formula (I) or salts thereof:
Inventor(s):	Johnson Paul David, Leach Andrew, Luke Richard William Arthur, Matusiak Zbigniew Stanley, Morris Jeffrey James
Assignee:	AstraZeneca AB
Application Number:	US16028979
Patent Claims:	3. The method according to claim 1 , wherein Z-Zrepresents CH═CH.4. The method according to claim 1 , wherein Rrepresents methoxyCalkyl claim 1 , fluoroCalkyl claim 1 , aminoCalkyl claim 1 , hydroxyCalkyl claim 1 , cyanoCalkyl claim 1 , Ccycloalkyl claim 1 , —(CH)NHCOCH claim 1 , —(CH)NHSOCH claim 1 , —(CH)NHCONH claim 1 , —(CH)NHCONRR claim 1 , —(CH)NRR claim 1 , —(CH)SONH claim 1 , —(CH)CONH claim 1 , —(CH)CONRRor —(CH)—R.5. The method according to wherein Rrepresents —(CH)—P claim 4 , p represents 1 claim 4 , 2 or 3 claim 4 , Ris selected from phenyl claim 4 , piperidinyl claim 4 , piperazinyl claim 4 , pyrrolidinyl claim 4 , morpholinyl claim 4 , imidazolyl claim 4 , isoxazolyl claim 4 , pyrazolyl and thiazolyl and Ris optionally substituted by a single methyl group.6. The method according to claim 1 , wherein Rrepresents hydroxyethyl.7. The method according to claim 1 , wherein Rrepresents chloro or bromo.8. The method according to claim 1 , wherein Rrepresents hydrogen.9. The method according to claim 1 , wherein n is 0 or 1.10. A method of treating breast cancer claim 1 , comprising administering to a person in need thereof a therapeutically effective amount of a pharmaceutical composition comprising: a compound according to claim 1 , or a pharmaceutically-acceptable salt thereof claim 1 , together with a pharmaceutically acceptable diluent or carrier.

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