Claims for Patent: 10,780,112

Summary for Patent: 10,780,112

Title:	Colonoscopy-preparation
Abstract:	The invention provides a colon cleansing solution comprising: a) 300 to 2000 mmol per litre ascorbate anion provided by ascorbic acid, one or more salts of ascorbic acid, or a mixture thereof; and b) 10 to 200 g per litre polyethylene glycol. The invention also provides methods and kits associated with, or making use of the solutions. The invention also provides a method of cleansing the colon of a subject comprising: --administering to the subject an effect amount of a first cleansing solution; and then after a time interval --administering to the subject an effective amount of a second cleansing solution, wherein the two cleansing solutions are as described in the specification.
Inventor(s):	Halphen; Marc (London, GB), Gruss; Hans-Jurgen (London, GB), Cox; Ian (London, GB), Cockett; Alasdair (London, GB), Stein; Peter (Amsterdam, NL), Ungar; Alex (Wigton, GB)
Assignee:	NORGINE BV (Amsterdam, NL)
Application Number:	16/788,590
Patent Claims:	1. A kit for preparation of a first colon cleansing solution and a second colon cleansing solution, comprising: (a) a first composition for preparation of the first colon cleansing solution, the first composition comprising: 75 to 150 g polyethylene glycol; 1 g to 10 g sodium sulphate; 1.5 g to 3.5 g sodium chloride; and 1.0 g to 2.5 g potassium chloride; and (b) a second composition presented in two parts for preparation of the second colon cleansing solution, the second composition comprising: 15 to 45 g polyethylene glycol; 1.5 g to 3.5 g sodium chloride; 1.0 g to 2.5 g potassium chloride; and 50 g to 60 g of an ascorbate component wherein the ascorbate component is provided by sodium ascorbate and ascorbic acid. 2. The kit of claim 1, wherein the first colon cleansing solution is free from ascorbic acid and salts thereof. 3. The kit of claim 1, wherein the weight ratio of sodium ascorbate to ascorbic acid is from 1:10 to 10:1. 4. The kit of claim 1, wherein the ascorbate component comprises 4.5 g to 55.5 g of sodium ascorbate and 4.5 g to 55.5 g of ascorbic acid. 5. The kit of claim 1, wherein the polyethylene glycol of the first composition is provided in an amount of 90 to 112.5 g. 6. The kit of claim 1, wherein the polyethylene glycol of the second composition is provided in an amount of 40 g. 7. The kit of claim 1, wherein the sodium sulphate of the first composition is provided in an amount of 9 g. 8. The kit of claim 1, wherein the first composition comprises a first sweetener. 9. The kit of claim 8, wherein the first sweetener is sucralose. 10. The kit of claim 9, wherein the second composition comprises a second sweetener. 11. The kit of claim 10, wherein the second sweetener is aspartame. 12. The kit of claim 1, wherein the first composition comprises citric acid. 13. The kit of claim 1, wherein the polyethylene glycol of the second composition is presented in one of the two parts and the ascorbate component is presented in the other of the two parts. 14. The kit of claim 1, wherein the first colon cleansing solution has a volume of 400 to 600 ml. 15. The kit of claim 1, wherein the first colon cleansing solution has a volume of 500 ml. 16. The kit of claim 1, wherein the second colon cleansing solution has a volume of 400 to 600 ml. 17. The kit of claim 1, wherein the second colon cleansing solution has a volume of 500 ml. 18. A kit for preparation of a first colon cleansing solution and a second colon cleansing solution, comprising: (a) a first composition for preparation of the first colon cleansing solution, the first composition consisting of: 75 to 150 g polyethylene glycol; 1 g to 10 g sodium sulphate; 1.5 g to 3.5 g sodium chloride; 1.0 g to 2.5 g potassium chloride; optionally one or more flavouring agents; optionally one of more sweeteners; and optionally with a taste enhancer of citric acid; and (b) a second composition presented in two parts for preparation of the second colon cleansing solution, the second composition consisting of: 15 to 45 g polyethylene glycol; 1.5 g to 3.5 g sodium chloride; 1.0 g to 2.5 g potassium chloride; and 50 g to 60 g of an ascorbate component; optionally one or more flavouring agents; and optionally one or more sweeteners wherein the ascorbate component is provided by sodium ascorbate and ascorbic acid. 19. The kit of claim 18, wherein the weight ratio of sodium ascorbate to ascorbic acid is from 1:10 to 10:1. 20. The kit of claim 18, wherein the ascorbate component comprises 4.5 g to 55.5 g of sodium ascorbate and 4.5 g to 55.5 g of ascorbic acid. 21. The kit of claim 18, wherein the polyethylene glycol of the first composition is provided in an amount of 90 to 112.5 g. 22. The kit of claim 18, wherein the polyethylene glycol of the second composition is provided in an amount of 40 g. 23. The kit of claim 18, wherein the sodium sulphate of the first composition is provided in an amount of 9 g. 24. The kit of claim 18, wherein the first composition comprises a first sweetener. 25. The kit of claim 24, wherein the first sweetener is sucralose. 26. The kit of claim 25, wherein the second composition comprises a second sweetener. 27. The kit of claim 26, wherein the second sweetener is aspartame. 28. The kit of claim 18, wherein the polyethylene glycol of the second composition is presented in one of the two parts and the ascorbate component is presented in the other of the two parts. 29. The kit of claim 18, wherein the first colon cleansing solution has a volume of 500 ml. 30. The kit of claim 18, wherein the second colon cleansing solution has a volume of 500 ml.