Claims for Patent: 10,806,733

Summary for Patent: 10,806,733

Title:	Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
Abstract:	Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
Inventor(s):	Metcalf; Brian (South San Francisco, CA), Chuang; Chihyuan (South San Francisco, CA)
Assignee:	Global Blood Therapeutics, Inc. (South San Francisco, CA)
Application Number:	16/017,248
Patent Claims:	1. A compound of Formula (I): ##STR00161## or a pharmaceutically acceptable salt thereof, wherein: Q is a pyridin-2-yl, pyridin-3-yl, or pyridin-4-yl, each of which is substituted with one R.sup.a; R.sup.2, R.sup.3, and R.sup.4 are each hydrogen; Y is CH.sub.2; X is O or CH.sub.2; R.sup.5 is halo or OH; R.sup.6 and R.sup.7 together form oxo; R.sup.a is heteroaryl substituted with one to three R.sup.c; and each R.sup.c is independently selected from the group consisting of C.sub.1-8alkyl and haloC.sub.1-8 alkyl. 2. The compound of claim 1, wherein X is 0. 3. The compound of claim 1, wherein R.sup.5 is OH. 4. The compound of claim 1, wherein R.sup.a is substituted with one R.sup.c, and R.sup.c is C.sub.1-6alkyl or haloC.sub.1-6alkyl. 5. The compound of claim 2, wherein: Q is pyridin-3-yl substituted with one R.sup.a. 6. The compound of claim 5, wherein R.sup.a is heteroaryl having two nitrogen ring atoms. 7. The compound of claim 6, wherein R.sup.a is substituted with one R.sup.c, and R.sup.c is C.sub.1-6alkyl or haloC.sub.1-6alkyl.