Claims for Patent: 10,835,515
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Summary for Patent: 10,835,515
| Title: | Carboxamide derivative and its diastereomers in stable crystalline form |
| Abstract: | The present disclosure relates to solid crystalline forms of N--((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-- hydroxyethyl)-1H-pyrazole-3-carboxamide (I) and the diastereomers thereof, and to methods for preparing such crystalline forms. Compound (I) and the diastereomers thereof are potent androgen receptor (AR) modulators useful as a medicament. ##STR00001## |
| Inventor(s): | Tormakangas; Olli (Turku, FI), Heikkinen; Terhi (Lieto, FI) |
| Assignee: | ORION CORPORATION (Espoo, FI) |
| Application Number: | 16/458,435 |
| Patent Claims: |
1. A pharmaceutical dosage form in the form of a tablet or a capsule for oral administration comprising crystalline form I of
N--((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl) propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide (I) having an X-ray powder diffraction pattern comprising characteristic peaks at about 8.5, 10.4, 16.6, 16.9, and 24.3 degrees 2-theta,
together with a pharmaceutical excipient.
2. The pharmaceutical dosage form according to claim 1, wherein the crystalline form I of N--((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl) propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide (I) further has an X-ray powder diffraction pattern comprising characteristic peaks at about 9.7, 15.9, 19.2, 21.8, and 25.5 degrees 2-theta. 3. A method for the treatment of prostate cancer comprising administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical dosage form according to claim 1 or 2. |
