Claims for Patent: 10,842,801

Summary for Patent: 10,842,801

Title:	Optimizing mifepristone absorption
Abstract:	The present invention provides a method for altering the pharmacokinetics of mifepristone upon oral administration. Mifepristone absorption into the blood is increased upon administration with meals. The method of the invention can benefit patients suffering from conditions including psychiatric illnesses and hormonal disorders.
Inventor(s):	Belanoff; Joe (Menlo Park, CA), Roe; Robert (Menlo Park, CA), Loewy; Caroline (Menlo Park, CA)
Assignee:	Corcept Therapeutics, Inc. (Menlo Park, CA)
Application Number:	16/574,780
Patent Claims:	1. A method of improving absorption of mifepristone in a patient suffering from Cushing's Syndrome, comprising administering to the patient for at least 7 days an oral dose of mifepristone of 900 mg per day within about 30 minutes after consuming a meal, such that the pharmacokinetics of mifepristone absorption are altered by increasing the maximum plasma concentration (C.sub.max) and increasing the area under the curve (AUC) as compared to the C.sub.max and AUC that would result from administering mifepristone without food in the fasted state in the absence of the meal, said increase in AUC being at least 44%, and thereby improving mifepristone absorption in the patient. 2. The method of claim 1, wherein the patient suffers from Cushing's disease. 3. The method of claim 1, wherein the daily oral dose of mifepristone is administered for at least 28 days. 4. The method of claim 1, wherein the mifepristone is administered as a single dose. 5. The method of claim 1, wherein the increase in AUC is between 44% and about 65%. 6. The method of claim 1, wherein the increase in C.sub.max is at least 34%. 7. The method of claim 1, wherein the increase in C.sub.max is between 34% and about 56%. 8. The method of claim 5, wherein the increase in C.sub.max is at least 34%. 9. The method of claim 5, wherein the increase in C.sub.max is between 34% and about 56%. 10. The method of claim 1, wherein the patient is a male. 11. The method of claim 1, wherein the patient is a female.