You're using a free limited version of DrugPatentWatch: Upgrade for Complete Access

Last Updated: April 9, 2025

Claims for Patent: 10,918,617

✉ Email this page to a colleague

« Back to Dashboard

Summary for Patent: 10,918,617

Title:	Fumarate ester pharmaceutical compositions
Abstract:	Described herein are pharmaceutical compositions comprising fumarate esters, methods for making the same, and methods for treating subjects in need thereof. In particular, oral pharmaceutical compositions comprising fumarate esters are described.
Inventor(s):	Dyakonov; Tatyana (Greensboro, NC), Agnihotri; Sunil (Scarborough, ME), Fatmi; Aqeel A. (High Point, NC)
Assignee:	BANNER LIFE SCIENCES LLC (High Point, NC)
Application Number:	16/129,908
Patent Claims:	1. An oral immediate release pharmaceutical composition comprising a single phase non-aqueous liquid vehicle comprising a suspension of a fumarate esters or a salt thereof having the formula: ##STR00002## wherein R.sub.1 and R.sub.2, may be the same or different, and independently represent hydrogen or methyl. 2. The composition of claim 1, wherein R.sub.1 is hydrogen. 3. The composition of claim 1, wherein R.sub.1 is methyl. 4. The composition of claim 1, wherein R.sub.2 is methyl. 5. The composition of claim 1, wherein R.sub.1 is hydrogen and R.sub.2 is methyl. 6. The composition of claim 1, wherein R.sub.1 is methyl and R.sub.2 is methyl. 7. The composition of claim 1, wherein the fumarate ester is: ##STR00003## or a salt thereof. 8. The composition of claim 1, wherein the fumarate ester is: ##STR00004## 9. The composition of claim 1, wherein the liquid vehicle comprises mono- and di-glycerides, polyvinylpyrrolidone, and polyoxyl 40 hydrogenated castor oil. 10. The composition of claim 1, wherein the liquid vehicle comprises lactic acid. 11. The composition of claim 1, wherein the composition comprises: about 25% to about 50% by weight of the composition of the one or more fumarate esters or salts thereof; about 40% to about 54% by weight of the composition of mono- and di-glycerides; about 1% to about 10% by weight of the composition of polyvinylpyrrolidone; about 2% to about 10% by weight of the composition of polyoxyl 40 hydrogenated castor oil; and about 5% b weight of the composition of lactic acid. 12. The composition of claim 1, wherein the composition is encapsulated in a capsule. 13. The composition of claim 1, wherein the composition is encapsulated in an enteric soft capsule. 14. The composition of claim 13, wherein the enteric soft capsule provides delayed release of the fumarate ester. 15. The composition of claim 1, wherein the fumarate ester is in the form of milled or micronized particles. 16. The composition of claim 11, wherein the composition is stable for at least 1 year at 25.degree. C.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.