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Last Updated: October 31, 2024

Claims for Patent: 10,953,003


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Summary for Patent: 10,953,003
Title:Methods for treating cancer
Abstract:The present invention relates to methods of treating patients with advanced forms of cancer, such as clear cell renal cell carcinoma, in which X4P-001 is administered in order to reduce angiogenic escape that typically occurs with TKI therapy. The methods demonstrate surprising results, including regression of tumor size and cell number, with comparatively little toxicity.
Inventor(s):Ragan Paula Marie, Arbeit Robert D., Crowley Kieran James
Assignee:
Application Number:US16061974
Patent Claims: 1. A composition comprising:(a) X4P-001, or a pharmaceutically acceptable salt thereof about 37% by weight of the composition;(b) microcrystalline cellulose about 23% by weight of the composition;(c) dibasic calcium phosphate dihydrate—about 32% by weight of the composition;(d) croscarmellose sodium—about 6% by weight of the composition;(e) sodium stearyl fumarate—about 1% by weight of the composition;(f) colloidal silicon dioxide—about 0.3% by weight of the composition; and(g) sodium lauryl sulfate—about 0.5% by weight of the composition.2. The composition according to claim 1 , wherein the X4P-001 claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , is present in an amount of about 10 mg claim 1 , about 20 mg claim 1 , about 25 mg claim 1 , about 50 mg claim 1 , about 75 mg claim 1 , about 100 mg claim 1 , about 150 mg claim 1 , about 200 mg claim 1 , about 250 mg claim 1 , about 300 mg claim 1 , about 400 mg claim 1 , about 450 mg claim 1 , about 500 mg claim 1 , about 600 mg claim 1 , about 700 mg claim 1 , about 750 mg claim 1 , about 800 mg claim 1 , about 900 mg claim 1 , about 1000 mg claim 1 , about 1100 mg claim 1 , or about 1200 mg.3. A composition comprising:(a) X4P-001, or a pharmaceutically acceptable salt thereof—about 14.7% by weight of the composition;(b) microcrystalline cellulose—about 78.1% by weight of the composition;(c) croscarmellose sodium—about 6.0% by weight of the composition;(d) sodium stearyl fumarate—about 1.0% by weight of the composition; and(e) colloidal silicon dioxide—about 0.2% by weight of the composition.4. The composition of claim 3 , wherein the composition comprises about 25 mg of X4P-001 claim 3 , or a pharmaceutically acceptable salt thereof.5. The composition of claim 1 , where the composition comprises about 100 mg of X4P-001 claim 1 , or a pharmaceutically acceptable salt thereof.6. The composition of claim 1 , wherein 3 claim 1 , where the composition comprises:(a) X4P-001, or a pharmaceutically acceptable salt thereof—about 37.6% by weight of the composition;(b) microcrystalline cellulose—about 22.9% by weight of the composition;(c) dibasic calcium phosphate dihydrate—about 31.7% by weight of the composition;(d) croscarmellose sodium—about 6.0% by weight of the composition;(e) sodium stearyl fumarate—about 1.0% by weight of the composition;(f) colloidal silicon dioxide—about 0.3% by weight of the composition; and(g) sodium lauryl sulfate—about 0.5% by weight of the composition.7. A composition comprising:(a) X4P-001, or a pharmaceutically acceptable salt thereof—about 61.5% by weight of the composition;(b) microcrystalline cellulose—about 12.9% by weight of the composition;(c) dibasic calcium phosphate dihydrate—about 17.8% by weight of the composition;(d) croscarmellose sodium—about 6.0% by weight of the composition;(e) sodium stearyl fumarate—about 1.0% by weight of the composition;(f) colloidal silicon dioxide—about 0.3% by weight of the composition; and(g) sodium lauryl sulfate—about 0.5% by weight of the composition.8. The composition of claim 7 , wherein the composition comprises about 200 mg of X4P-001 claim 7 , or a pharmaceutically acceptable salt thereof.9. A unit dosage form comprising the composition of .10. The unit dosage form of claim 9 , wherein the unit dosage form is in the form of a capsule.11. A unit dosage form comprising the composition of .12. The unit dosage form of claim 11 , wherein the unit dosage form is in the form of a capsule.13. A unit dosage form comprising the composition of .14. The unit dosage form of claim 13 , wherein the unit dosage form is in the form of a capsule.

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