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Last Updated: November 22, 2024

Claims for Patent: 10,973,811

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Summary for Patent: 10,973,811

Title:	Pharmaceutical compositions and methods of using the same
Abstract:	Novel pharmaceutical compositions including cocaine hydrochloride and methods of treating patients using those pharmaceutical compositions are described.
Inventor(s):	Moshal; Jeffrey M. (Allentown, PA), Libman; Michael (Allentown, PA)
Assignee:	GENUS LIFESCIENCES INC. (Allentown, PA)
Application Number:	16/563,454
Patent Claims:	1. A method of administering a local anesthetic prior to performing a diagnostic or surgical procedure on a renally impaired subject comprising: soaking one or more pledgets in up to about 4 mL of a ready-to-use composition comprising about 3.6% to about 4.4% cocaine hydrochloride, by weight, a preservative, an acidulant, and optionally, at least one coloring additive; contacting each pledget on a nasal mucous membrane of the subject up to about 20 minutes; and removing each pledget from contact with a mucous membrane. 2. The method of claim 1, wherein, the renally impaired subject has an estimated glomerular filtration rate (eGFR) in the range of about 15 mL/min./1.73 m.sup.2 to less than 60 mL/min./1.73 m.sup.2. 3. The method of claim 1, wherein, the renally impaired subject has an estimated glomerular filtration rate (eGFR) in the range of about 15 mL/min./1.73 m.sup.2 to less than about 29 mL/min./1.73 m.sup.2. 4. The method of claim 1, wherein the procedure comprises nasal endoscopy. 5. The method of claim 1, wherein the procedure comprises nasal laryngoscopy. 6. The method of claim 1, wherein the procedure comprises nasal debridement. 7. The method of claim 1, wherein the procedure comprises nasopharyngeal laryngoscopy. 8. The method of claim 1, wherein the procedure comprises laryngoscopy. 9. The method of claim 1, wherein the method achieves an absorptivity factor for cocaine in the subject in the range of 0.640 h.sup.-1 to 0.687 h.sup.-1. 10. The method of claim 1, wherein the method achieves an absorptivity factor for cocaine in the subject in the range of 0.483 h.sup.-1 to 0.789 h.sup.-1.

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