Claims for Patent: 11,033,696

Summary for Patent: 11,033,696

Title:	Nasal delivery devices
Abstract:	A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece (117) for fitting to a nasal cavity of a subject; a mouthpiece (119) into which the subject in use exhales; a delivery unit, which comprises an actuation part which is manually displaceable to actuate the delivery unit to deliver substance from the nosepiece; and a valve assembly (127) which is fluidly connected to the nosepiece and the mouthpiece, wherein the valve assembly comprises a body element (128) and a valve element (131) which is movably disposed to the body element between closed and open configurations by manual displacement of the actuation part of the delivery unit to provide for an air flow through the nosepiece simultaneously with delivery of substance.
Inventor(s):	Djupesland; Per Gisle (Oslo, NO), Leclerc; Michael (Cranston, RI), Mahmoud; Ramy A (Skillman, NJ), Siwinski; Shane (Barrington, RI), Gordon; Joseph (Mansfield, MA), Fisk; Justin (Providence, RI)
Assignee:	OptiNose AS (Oslo, NO)
Application Number:	16/093,174
Patent Claims:	1. A nasal delivery device for delivering substance to a nasal airway of a subject, comprising: a nosepiece for fitting to a nasal cavity of the subject; a nozzle for delivering the substance through the nosepiece and to the nasal airway of the subject; a mouthpiece for fitting to an oral cavity of the subject and configured to receive, in use, a flow of exhalation breath from the subject; a valve disposed between the mouthpiece and the nosepiece and configured to selectively move from a first position, substantially blocking the flow of exhalation breath between the mouthpiece and the nosepiece, to a second position, permitting the flow of exhalation breath between the mouthpiece and the nosepiece; a substance chamber containing the substance to be delivered; and a pump configured to selectively deliver the substance from the substance chamber to the nozzle; the valve including a valve seat, defining a valve opening, and a valve element, including a seal and an arm connected to the seal, wherein the seal is biased into sealing engagement with the valve seat when the valve is in the first position; and an actuator configured to selectively move the valve from the first position to the second position to move the seal out of sealing engagement with the valve seat by engaging a portion of the arm when the substance chamber is actuated. 2. The nasal delivery device of claim 1, further comprising a housing having an aperture wherein the substance chamber extends out of the housing through the aperture. 3. The nasal delivery device of claim 2, wherein the substance chamber is selectively movable relative to the housing. 4. The nasal delivery device of claim 3, wherein movement of the substance chamber actuates the pump. 5. The nasal delivery device of claim 4, wherein the substance chamber is configured to be manually movable relative to the housing such that manual movement of the substance chamber actuates the pump. 6. The nasal delivery device of claim 1, wherein the substance is a liquid. 7. The nasal delivery device of claim 1, wherein the substance is a powder. 8. The nasal delivery device of claim 1, wherein the substance is a vaccine. 9. The nasal delivery device of claim 1, wherein the nozzle is configured to deliver an aerosol spray. 10. The nasal delivery device of claim 1, wherein the valve substantially blocks the exhalation flow when in the first position with an efficiency of less than 5 L/min when the exhalation flow is at a pressure of 3 kPa. 11. The nasal delivery device of claim 1, wherein the valve substantially blocks the exhalation flow when in the first position with an efficiency of 0 L/min when the exhalation flow is at a pressure of 3 kPa. 12. The nasal delivery device of claim 1, wherein the nasal delivery device is configured to provide at least 80% of the exhalation flow to the nosepiece when delivered at a flow rate of 50 L/min and an exhalation pressure of 3 kPa. 13. The nasal delivery device of claim 1, wherein the nasal delivery device is configured such that the pump provides for delivery of the substance in a period less than about 250 ms after the valve is selectively moved from the first position. 14. The nasal delivery device of claim 1, wherein the pump is configured to deliver at least one metered dose of the substance. 15. The nasal delivery device of claim 14, wherein the substance is a liquid. 16. The nasal delivery device of claim 14, wherein the substance is a powder. 17. The nasal delivery device of claim 14, wherein the substance is an aerosol. 18. The nasal delivery device of claim 14, wherein the pump is configured to deliver a plurality of metered doses of the substance. 19. The nasal delivery device of claim 18, wherein the substance is a liquid. 20. The nasal delivery device of claim 18, wherein the substance is a powder. 21. The nasal delivery device of claim 18, wherein the substance is an aerosol. 22. The nasal delivery device of claim 1, wherein the nasal delivery device is configured to deliver the substance to the nasal cavity while delivering the exhalation flow to the nasal cavity. 23. The nasal delivery device of claim 1, wherein the nasal delivery device is configured to deliver the substance and exhalation flow out of the nosepiece. 24. A nasal delivery device for delivering substance to a nasal airway of a subject, comprising; a nosepiece for fitting to a nasal cavity of the subject; a nozzle for delivering the substance through the nosepiece and to the nasal airway of the subject; a mouthpiece for fitting to an oral cavity of the subject and configured to receive, in use, a flow of exhalation breath from the subject; a substance chamber containing the substance to be delivered and configured to be manually actuated and moved from a first position to a second position; a pump configured to be actuated in response to manual actuation of the substance chamber to deliver the substance from the substance chamber to the nozzle; a valve disposed between the mouthpiece and the nosepiece, the valve including a valve seat defining a valve opening, and a valve element including a seal and an arm connected to the seal, wherein the seal is biased into sealing engagement with the valve seat when the valve is in a first position; and an actuator configured to selectively move the valve from the first position to a second position to move the seal out of sealing engagement with the valve seat by engaging a portion of the arm when the substance chamber is actuated. 25. The nasal delivery device of claim 24, wherein the pump is configured to deliver at least one metered dose of the substance. 26. The nasal delivery device of claim 25, wherein the substance is a liquid. 27. The nasal delivery device of claim 25, wherein the substance is a powder. 28. The nasal delivery device of claim 25, wherein the substance is an aerosol. 29. The nasal delivery device of claim 24, wherein the pump is configured to deliver a plurality of metered doses of the substance. 30. The nasal delivery device of claim 29, wherein the substance is a liquid. 31. The nasal delivery device of claim 29, wherein the substance is a powder. 32. The nasal delivery device of claim 29, wherein the substance is an aerosol.