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Last Updated: November 4, 2024

Claims for Patent: 11,103,477

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Summary for Patent: 11,103,477

Title:	Stable pharmaceutical composition and methods of using same
Abstract:	The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.
Inventor(s):	Manku; Mehar (Birmingham, GB), Osterloh; Ian (Kent, GB), Wicker; Pierre (Mystic, CT), Braeckman; Rene (Richboro, PA), Soni; Paresh (Mystic, CT)
Assignee:	Amarin Pharmaceuticals Ireland Limited (Dublin, IE)
Application Number:	17/016,577
Patent Claims:	1. A method of reducing a risk of myocardial infarction in a subject on statin therapy having atrial fibrillation or atrial flutter and elevated triglyceride levels, the method comprising administering to the subject about 4 g of ethyl eicosapentaenoate per day. 2. The method of claim 1, wherein the subject has a baseline LDL-C level of about 40 mg/dL to about 100 mg/dL. 3. The method of claim 1, wherein the ethyl eicosapentaenoate is present in a pharmaceutical composition and the ethyl eicosapentaenoate comprises at least about 96 wt. % of all omega-3 fatty acids in the pharmaceutical composition. 4. The method of claim 3, wherein about 1 g of the pharmaceutical composition is present in each of 4 capsules. 5. The method of claim 1, wherein the subject has elevated triglyceride levels of at least about 300 mg/dL. 6. The method of claim 1, wherein the subject has elevated triglyceride levels of at least about 500 mg/dL. 7. The method of claim 1, wherein the subject has elevated triglyceride levels of about 500 mg/dl to about 1500 mg/dl.

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