Claims for Patent: 11,197,830

Summary for Patent: 11,197,830

Title:	Pharmaceutical composition containing acetaminophen and ibuprofen
Abstract:	Solid oral dosage forms containing 325 mg of acetaminophen and 97.5 mg of ibuprofen or 500 mg of acetaminophen and 150 mg of ibuprofen, wherein the ibuprofen has a [D50] between 1 and 9 μm, are described.
Inventor(s):	Murphy Maura, Callahan Matt
Assignee:
Application Number:	US16287836
Patent Claims:	2. The tablet of claim 1 , wherein the ibuprofen has a [D10] between 1 and 3 μm.3. The tablet of claim 1 , wherein the ibuprofen has a [D90] between 3 and 16 μm.4. The tablet of claim 1 , wherein the ibuprofen has a [D50] between 2 and 8 μm claim 1 , a [D10] between 1 and 3 μm and a [D90] between 4 and 16 μm.5. The tablet of wherein the dissolution rate of ibuprofen in the solid oral dosage form is such that claim 1 , when tested using USP Apparatus II (paddles) set to rotation speed of 50 rpm in 900 mL of 50 mM pH 5.8 phosphate buffer at 37° C. claim 1 , wherein 80% or more of the ibuprofen dissolves in 15 minutes or less.6. The tablet of claim 5 , wherein at least 85% to 95% of the ibuprofen dissolves in 15 minutes or less.7. The tablet of claim 5 , wherein at least 95% to 100% of the ibuprofen dissolves in 10 minutes or less.8. The tablet of claim 1 , wherein the tablet is coated.9. The tablet of claim 1 , wherein the [D90] to [D50] ratio is between 3:1 and 1.5:1.10. The tablet of claim 1 , wherein the [D50] to [D10] ratio is between 4:1 and 1.5:1.11. The tablet of claim 1 , wherein the [D50] to [D10] ratio is between 3:1 and 1.5:1.12. The tablet of claim 1 , wherein the tablet is a coated tablet.13. The tablet of claim 1 , prepared by a process comprising jet milling a composition comprising 21-23% wt/wt ibuprofen and 73-75% wt/wt acetaminophen.14. The tablet of claim 1 , wherein the surfactant is sodium lauryl sulfate.15. The tablet of claim 5 , wherein 85% to 95% of the ibuprofen dissolves in 15 minutes.16. The tablet of claim 5 , wherein 95% to 100% of the ibuprofen dissolves in 10 minutes.17. A method for treating pain comprising administering a dose of 1 claim 1 , 2 or 3 units of the tablet of comprising 325 mg of acetaminophen and 97.5 mg of ibuprofen.18. The method of claim 17 , wherein the administration is 1 claim 17 , 2 claim 17 , 3 or 4 times daily.19. A method for treating pain comprising administering a dose of 1 or 2 units of the solid oral dosage form of comprising 500 mg of acetaminophen and 150 mg of ibuprofen.20. The method of claim 19 , wherein the administration is 1 claim 19 , 2 claim 19 , 3 or 4 times daily.21. The method of claim 17 , wherein the pain is mild to moderate acute pain.